Mitochondrial dynamics in mammalian health and disease.

By M. Liesa, M. Palacín, Antonio Zorzano. Physiological Reviews, 2009

943 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f384ca07b70e6802e60d9944b142a4e7b8f3211b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Clinical Biochemistry

In Molecular Biology

Citations in the corpus

Mechanisms of mitochondrial fission and fusion. (2013, background): “Many of these diseases are neurodegenerative (Parkinson’s, CharcotMarie-Tooth, Dominant Optic Atrophy, and Alzheimer’s), but effects on other tissues have also been observed (diabetes, ischemia reperfusion, and liver disease) (Liesa et al. 2009; Chan 2012; Nunnari and Suomalainen 2012).”
Autophagy proteins regulate innate immune response by inhibiting NALP3 inflammasome-mediated mitochondrial DNA release (2010, positive): “Impaired caspase-1 activation in ρ 0 macrophages Mitochondrial abnormalities have been linked to the pathogenesis of human diseases, such as type II diabetes, Parkinson's disease and Alzheimer's diseas”
Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin (2010, background): “Numerous elegant studies have demonstrated that the mitochondrial network is extremely dynamic and responds rapidly and reversibly to many physiological changes including potentially toxic challenges such as oxidative stress and calcium flux (reviewed in (41, 42)).”
MiD49 and MiD51, new components of the mitochondrial fission machinery (2011, background): “Mitochondria are dynamic organelles that undergo fission and fusion events and are distributed along cytoskeletal elements (Frazier et al, 2006; Liesa et al, 2009; Westermann, 2010).”
Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis (2012, background): “M morphology, response to apoptotic stimuli, mitochondrial metabolism, and quality control are in part controlled through the balance between mitochondrial fusion and fission (1, 2).”
Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure (2013, background): “Multiple evidences demonstrate that mitochondrial dynamics are important for cell viability, senescence, mitochondria health, bioenergetic function, quality control, and intracellular signaling (reviewed in Liesa et al., 2009; reviewed in Twig et al., 2008b).”
Mitochondrial dynamics regulates migration and invasion of breast cancer cells (2012, background): “Altered mitochondrial dynamics has been linked to altered mitochondrial physiology and abnormal cell functions (15, 16), which has been implicated in many human diseases (17).”
The Interplay Between Mitochondrial Dynamics and Mitophagy (2011, background): “Mitochondrial dynamics refers to repetitive cycles of fusion and fission between mitochondria (56, 97, 119).”