SLP‐2 is required for stress‐induced mitochondrial hyperfusion

By Daniel Tondera, S. Grandemange, Alexis A. Jourdain, M. Karbowski, Yves Mattenberger, S. Herzig, Sandrine Da Cruz, Pascaline Clerc, I. Raschke, Carsten Merkwirth and 8 more. EMBO Journal, 2009

791 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f7653e851513a6e37830b25808188c4acf4a1d3f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Clinical Biochemistry

In Molecular Biology

Citations in the corpus

Mitochondria: In Sickness and in Health (2012, background): “…UV exposure, cycloheximide treatment, and nutrient deprivation, stimulate Cell 148, March 16, 2012 ª2012 Elsevier Inc. 1149 mitochondrial fusion to generate branched and interconnected organelles and improve cell survival (Gomes et al., 2011a, 2011b; Rambold et al., 2011; Tondera et al., 2009).”
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability (2011, background): “For example, in cells exposed to several stresses, a change in the relative levels of the forms of the pro-fusion OPA1 supports mitochondrial elongatio”
Metabolic regulation of mitochondrial dynamics (2016, background): “Elongated mitochondria have also been observed in other conditions associated with increased ATP production (Mitra et al., 2009; Tondera et al., 2009).”
Mitochondria in Apoptosis: Bcl-2 family Members and Mitochondrial Dynamics (2011, background): “Moreover, previous data have shown that stress-induced mitochondrial hyperfusion, which leads to highly elongated organelles, delays Bax activation upon exposure of cells to apoptotic stimuli (Tondera et al., 2009).”
Mitochondrial Cristae: Where Beauty Meets Functionality. (2016, background): “Depletion of PHBs in murine cells affected OPA1 function and led to changes in mitochondrial morphology [4,55]; moreover, PHBs influence the turnover rates of respiratory chain[7_TD$DIFF] complexes[17_TD$DIFF] subunits [56] and impact the assembly of complex IV [57].”
The Interplay Between Mitochondrial Dynamics and Mitophagy (2011, background): “Although under some conditions, mitochondria hyperfuse as a first line of defense to nonmitochondrial metabolic insults (109), other insults that directly affect mitochondrial metabolism are associated with significant unbalanced fission mainly because of a decreased fusion rate (also referred to as”
Fatty acid trafficking in starved cells: regulation by lipid droplet lipolysis, autophagy and mitochondrial fusion dynamics (2015, background): “Emerging evidence is also correlating the presence of fused mitochondria with many cellular states of high-energy demand, including G1/S cell-cycle transition (Mitra et al., 2009) and chemical stress (Tondera et al., 2009).”
Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure (2013, background): “These changes were shown to facilitate ATP synthesis (Jendrach et al., 2008; Tondera et al., 2009).”
Mitochondrial fusion and fission in cell life and death (2010, background): “Moreover, mitochondrial fusion is markedly increased under stress conditions that involve mitochondrial ATP productio”
Mechanisms of mitochondrial fission and fusion. (2013, background): “This phenomenon is called stress-induced mitochondrial hyperfusion (SIMH) (Tondera et al. 2009).”
Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation (2011, background): “We also cannot rule out additional mechanisms like the involvement of SLP-2, which can stabilize the long isoforms of Opa-1 under low-stress conditions (22).”