Reversible phosphorylation of Drp1 by cyclic AMP‐dependent protein kinase and calcineurin regulates mitochondrial fission and cell death

By J. Cribbs, Stefan Strack. EMBO Reports, 2007

1,026 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/717a34bb7007d7f0dd545e646459e4f1d671f755

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In Cell Biology

1. D. C. Chan
2. D. Suen
3. L. Scorrano
4. R. Youle
5. M. Liesa
6. Prashant Mishra
7. Kristi L. Norris
8. W. Ding

In Molecular Biology

1. D. C. Chan
2. R. Youle
3. Hsiuchen Chen
4. M. Liesa
5. L. Scorrano
6. Prashant Mishra
7. A. M. van der Bliek
8. W. Ding

Citations in the corpus

• The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. (2008, background): “Reversal of PKA phosphorylation by the calcium-dependent phosphatase calcineurin triggers mitochondrial fission (Cribbs and Strack, 2007).”
• Metabolic regulation of mitochondrial dynamics (2016, background): “Phosphorylation at S637 is counteracted by the phosphatases calcineurin (Cribbs and Strack, 2007; Cereghetti et al., 2008) and PP2A/Bβ2 (Dickey and Strack, 2011).”
• Mitochondrial dynamics in health and disease: mechanisms and potential targets (2023, background): “111,112 The Bcl-2 protein family plays a crucial role in regulating the release of proapoptotic molecules from the IMS to the cytoplasm and maintaining the integrity of the OMM.”
• Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission (2013, background): “Phosphorylation of Drp1 at S637 has been shown to negatively regulate Drp1 function (Chang and Blackstone, 2007; Cribbs and Strack, 2007; Cereghetti et al., 2008).”
• Mitochondrial dynamics and mitochondrial quality control (2014, background): “Presenilin-associatedrhomboid-like (PARL) [13] and paraplegin (an AAA protease present in the mitochondrial matrix) [14] induce alternative splicing and alternative processing of OPA1 to generate eight OPA1 isoforms.”
• Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha. (2008, background): “45 Activation of the p38 mitogen-activated protein kinase (MAPK) pathway in skeletal muscle has been shown to promote PGC-1 a expression.”
• Mechanisms of mitochondrial fission and fusion. (2013, background): “These sites include Ser616, which is phosphorylated by protein kinase C (PKC) d, Rock kinase, CDK1/ Cyclin B or CAMK-Ia (Taguchi et al. 2007; Han et al. 2008; Qi et al. 2011; Wang et al. 2012), and Ser637, which is phosphorylated by protein kinase A (PKA) (Chang and Blackstone 2007; Cribbs and Strac”
• Mitochondrial fragmentation in neurodegeneration (2008, background): “Protein kinase A (PKA) phosphorylates DRP1 at Ser637 in the variable domain of humans and at Ser656 in the conserved GED of rat”
• Mitochondrial dynamics and apoptosis. (2008, positive): “Conversely, Drp1 GTPase activity is inactivated by phosphorylation at Ser637 (human Drp1; Ser656 in rat Drp1) within the GTPase effector domain (GED) mediated by cAMP-dependent protein kinase A (PKA), resulting in mitochondrial fusion (Chang and Blackstone 2007; Cribbs and Strack 2007).”