The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

By Hansong Deng, M. Dodson, Haixia Huang, Mingwei Guo. Proceedings of the National Academy of Sciences of the United States of America, 2008

721 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/7947e884f866edf15cee11c092d7c0aaf4bb71c7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

In Molecular Biology

In Neurology

Citations in the corpus

The Interplay Between Mitochondrial Dynamics and Mitophagy (2011, background): “In Drosophila and COS7 cells, mutants for PINK1 and Parkin had elongated mitochondria (19, 81, 88, 123), whereas in other mammalian systems this manipulation 1946 TWIG AND SHIRIHAI”
Mechanisms of mitophagy (2011, background): “, which can lead to loss of flight muscle and dopaminergic neurons, and to male sterility that is ameliorated by promotion of mitochondrial fissio”
Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin (2010, background): “In particular, that promoting mitochondrial fragmentation, by overexpression of Drp1 or reduction of Mfn and Opa1, is able to partially suppress the locomotor deficits, muscle degeneration and mitochondrial abnormalities (9-12).”
Genetic Animal Models of Parkinson’s Disease (2010, positive): “Additional studies suggest that parkin and PINK1 regulate mitochondrial trafficking and/or autophagy (Deng et al., 2008; Narendra et al., 2010; Poole et al., 2008; Vives-Bauza et al., 2010; Yang et al., 2008).”
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy (2008, background): “Recent genetic studies have linked Parkin activity to gene products controlling mitochondrial fi ssion and fusion ( Deng et al., 2008 ; Poole et al., 2008 ; Yang et al., 2008 ), which suggests that Parkin recruitment to mitochondria may be a consequence of depolarizationinduced fragmentation.”
Impaired Balance of Mitochondria Fission and Fusion in Alzheimer Disease (2009, background): “…mitochondria in neurons, impaired mitochondrial dynamics is increasingly implicated in neurodegenerative diseases including Parkinson and Huntington diseases (Exner et al., 2007; Deng et al., 2008; Mortiboys et al., 2008; Poole et al., 2008; Yang et al., 2008; Park et al., 2009; Wang et al., 2009).”
Mitochondria: In Sickness and in Health (2012, background): “In flies, attenuation of mitochondrial fusion or stimulation of mitochondrial division can rescue phenotypes associated with PINK1 or Parkin mutants, and loss of division exacerbates these phenotypes and causes lethality (Deng et al., 2008; Poole et al., 2008).”
The Roles of PINK1, Parkin and Mitochondrial Fidelity in Parkinson's Disease (2015, background): “The silencing of Marf or OPA1 or the overexpression of Drp1 reverted the mitochondrial morphology and biochemical deficits exhibited in PINK1- and Parkin-mutant flies (Deng et al., 2008; Liu et al., 2011; Park et al., 2009; Poole et al., 2008; Yang et al., 2008).”
Mitochondria, oxidative stress and neurodegeneration. (2012, background): “There is evidence that PINK1 and parkin may play a role in the same pathway, probably affecting the balance between mitochondrial fission and fusion [65].”
Mitochondrial fusion and fission in cell life and death (2010, background): “melanogaster have revealed many genetic interactions of PINK1 and Parkin with fusion and fission component”
The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice (2009, background): “Abnormalities in division have also been implicated in Charcot-Marie-Tooth type 4A, Parkinson’s disease, Alzheimer’s disease, and abnormal brain development (Cuesta et al., 2002; Waterham et al., 2007; Deng et al., 2008; Poole et al., 2008; Yang et al., 2008; Cho et al., 2009).”
Mitochondrial dynamics–fusion, fission, movement, and mitophagy–in neurodegenerative diseases (2009, background): “In the testicular mitochondria, however, a pink1 mutation is epistatic to an fzo mutation (61).”