Mitochondria, oxidative stress and neurodegeneration.

By A. Federico, E. Cardaioli, P. Da Pozzo, P. Formichi, G. Gallus, E. Radi. Journal of Neurological Sciences, 2012

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Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF (2015, background): “Moreover, compared to nuclear DNA the mitochondrial DNA is particularly vulnerable to ROS-mediated damage [23, 35].”
Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications (2017, background): “Like many neural disorders mentioned previously, SCA is linked with mitochondrial dysfunction [21, 137].”
The Role of Oxidative Stress in Neurodegenerative Diseases (2015, background): “Cumulative oxidative stress may induce cellular damage, impairment of the DNA repair system [3], and mitochondrial dysfunction, all of which have been known as key factors in acceleration of aging process and the development of neurodegenerative disorders [2, 4, 5].”
Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders (2017, background): “In this regard, in age-related NDDs such as Alzheimer’s disease (AD), Huntington’s disease (HD), Amyotrophic lateral sclerosis (ALS) and PD mitochondria play an important role.[23] Mitochondria are the”
Oxidative Stress: A Key Modulator in Neurodegenerative Diseases (2019, background): “Enrichment of mitochondria with various redox enzymes and mitochondrial dysfunction is supposed to be responsible for production of ROS in the cellular environment (Figure 3) [22,23].”