The role of pH in determining the species composition of the human colonic microbiota.

By S. Duncan, P. Louis, J. Thomson, H. Flint. Environmental Microbiology, 2009

710 citations recorded by the source corpus.

Subfields: Food Science, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/66560c59aeb1ddbddbee5c2df34dde33f1dfbe26

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Food Science

1. H. Flint
2. P. Louis
3. K. Scott
4. S. Duncan
5. G. Holtrop
6. H. Holscher
7. Pauline Young
8. F. Leroy

In Infectious Diseases

1. H. Flint
2. P. Louis
3. J. Cryan
4. Ted G. Dinan
5. F. Bäckhed
6. C. Stanton
7. E. Quigley
8. G. Clarke

In Molecular Biology

1. H. Flint
2. J. Cryan
3. P. Louis
4. Ted G. Dinan
5. S. Duncan
6. G. Clarke
7. F. Bäckhed
8. K. Scott

Citations in the corpus

• Dietary fiber and prebiotics and the gastrointestinal microbiota (2017, background): “, while reducing the proliferation of the acid sensitive Bacteroides spp.(70,71)”
• Differential Adaptation of Human Gut Microbiota to Bariatric Surgery–Induced Weight Loss (2010, neutral): “coli was facilitated by increased pH (29).”
• Butyrate-producing Clostridium cluster XIVa species specifically colonize mucins in an in vitro gut model (2012, background): “Furthermore, as opposed to the luminal content where the pH was maintained constant, local accumulation of acids in mucus may cause a lower pH, selecting for Firmicutes over Bacteroidetes and Proteobacteria (Duncan et al., 2009).”
• Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation (2015, background): “coli in vitro (Duncan et al., 2009), and both RYGB and VBG are associated with reduced luminal exposure to gastric acidity.”
• High-protein, reduced-carbohydrate weight-loss diets promote metabolite profiles likely to be detrimental to colonic health. (2011, background): “driven by the increased pH (26, 35) and reduced supply of resistant starch with the HPLC diet.”
• Formation of propionate and butyrate by the human colonic microbiota. (2017, background): “This is because human colonic Bacteroides spp. are generally less able than many dominant Firmicutes to tolerate the presence of short chain fatty acids at pH 5.5 (Duncan et al., 2009).”
• Phylogenetic distribution of three pathways for propionate production within the human gut microbiota (2014, background): “Thus, pH is an important determinant in the competition between Bacteroidetes and Firmicutes (Walker et al., 2005; Duncan et al., 2009), and the level of propionate production in Bacteroidetes is dependent on carbon dioxide levels (Macfarlane and Gibson, 1997).”
• The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis? (2016, background): “, 1987) which is in line with butyrogenic bacteria being able to proliferate at a lower pH as compared to gram negative Bacteroides species, more prevalent at a higher pH (Duncan et al., 2009; Walker et al., 2005).”
• An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota (2011, background): “varied for different species but, overall, the Clostridium cluster XIVa group showed the smallest reduction in growth rate, while the butyrate-producing associated Clostridium cluster IV growth rates were dramatically reduced.(45) We detected no significant change in the overall abundance of Clostri”
• The Impact of Diet and Lifestyle on Gut Microbiota and Human Health (2014, background): “dependent on many factors, including nutrient availability and the luminal environment, particularly pH [10].”
• Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut (2016, background): “This is to be explained by a stimulation of saccharolytic activities, an increase in SCFA production, and a lowering of the luminal pH in the distal part of the colon, where carbohydrates are rare and proteolytic bacteria, such as Bacteroides spp., are otherwise favored (Duncan et al., 2009).”
• SCFA: mechanisms and functional importance in the gut (2020, background): “In vitro experiments have shown that Bacteroides growth is reduced relative to Firmicutes and Actinobacteria because SCFA negatively impact Bacteroides at mild acid pH((31)).”