Phylogenetic distribution of three pathways for propionate production within the human gut microbiota

By Nicole Reichardt, S. Duncan, Pauline Young, A. Belenguer, C. Leitch, K. Scott, H. Flint, P. Louis. The ISME Journal, 2014

1,145 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/2a44e65624f71a4e64bf34721959211dff86736e

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Citations in the corpus

Specific microbiome-dependent mechanisms underlie the energy harvest efficiency of ruminants (2016, background): “It should be noted that this pathway is encoded in the genome of M. elsdenii (Prabhu et al., 2012) and Coprococcus catus (Reichardt et al., 2014), which were both found by the analyses to be significantly enriched in efficient animals' microbiomes (Figures 5 and 6a, Supplementary Figure S15), and…”
Formation of propionate and butyrate by the human colonic microbiota. (2017, background): “Phascolarctobacterium succinatutens; Watanabe et al., 2012), have the ability to convert succinate to propionate (Flint et al., 2014; Reichardt et al., 2014).”
Gut microbiota functions: metabolism of nutrients and other food components (2017, background): “Ruminococcus obeum produces acetate, formate, and lactate during growth on glucose on pure culture, but additionally produces propionate during growth on fucose, again using the propanediol utilization pathway [18].”
Gut Microbiota-Derived Short-Chain Fatty Acids, T Cells, and Inflammation (2014, neutral): “such as pentoses, hexoses, and rhamnose (31).”
The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome (2020, neutral): “commensal acetic, propionic, butyric [33,34,36,37]”
Short chain fatty acids in human gut and metabolic health. (2020, positive): “The propanediol pathway detected, using the pduP gene encoding propionaldehyde dehydrogenase, that processes deoxy sugars such as fucose and rhamnose was more prevalent within the Lachnospiraceae occurring in relatives of Ruminococcus obeum and in Roseburia inulinivorans (Reichardt et al. , 2014) .”
Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism (2016, background): “For example, propionate production although distributed across a number of phyla is dominated by relatively few bacterial genera.(13) Species such as Akkermansia municiphilla have been identified as key propionate producing mucin degrading organisms.”
The Controversial Role of Human Gut Lachnospiraceae (2020, background): “inulinivorans and Blautia species, leading to the production of propionate and propanol from deoxy sugars fucose and rhamnose [27,41].”
Understanding the Holobiont: How microbial metabolites affect human health and shape the immune system (2017, background): “Similarly, lactate, which is produced by many members of the human gut microbiome, has been shown to serve as substrate for bacterial production of propionate (e.g., Coprococcus catus) and butyrate (e.g., Eubacterium hallii andAnaerostipes caccae) (Duncan et al., 2004b; Reichardt et al., 2014).”
Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota (2023, background): “, fucose and rhamnose) are processed [85].”
Microbiota metabolite short chain fatty acids, GCPR, and inflammatory bowel diseases (2016, background): “across a number of phyla, propionate production is dominated by relatively few bacterial genera [25].”
The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health (2021, background): “Although propionate-producers are distributed across several phyla, only a few bacterial genera are able to form propionate, and unlike acetate, the utilized propionate pathways are more conserved and substrate specific.(83) Propionate can be synthesized through three different biochemical pathways,”