High-protein, reduced-carbohydrate weight-loss diets promote metabolite profiles likely to be detrimental to colonic health.

By W. Russell, S. Gratz, S. Duncan, G. Holtrop, J. Ince, L. Scobbie, G. Duncan, Alexandra M. Johnstone, G. Lobley, R. Wallace and 2 more. American Journal of Clinical Nutrition, 2011

713 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/0f3900ccebf35c8bd20c195b2d4f41102f5f8fa9

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In Molecular Biology

1. P. Louis
2. H. Flint
3. K. Scott
4. F. Bäckhed
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In Physiology

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7. M. Conlon
8. A. Bird

Citations in the corpus

• Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration (2019, methodology): “Russell [70] 2011 Humans 17 Randomised cross-over NA Two treatment groups: (1) high-protein and moderate-carbohydrate diet (HPMC) (4 weeks); (2) high-protein and low carbohydrate diet (HPLC) (4 weeks).”
• The role of short-chain fatty acids in immunity, inflammation and metabolism (2020, background): “At present, studies have revealed that adding dietary fiber to a diet rich in fat or protein can restore the level of beneficial microbial metabolites and reduce the level of harmful microbial metabolites such as increased production of short-chain fatty acids (Sanchez et al. 2009).”
• Mechanisms and consequences of intestinal dysbiosis (2017, background): “In obese men, the consumption of a proteinrich diet did not affect the abundance of Bacteroides, but the Roseburia/Eubacterium rectale group of bacteria was reduced probably due to lower carbohydrate intake [39].”
• Intestinal Blautia is associated with reduced death from graft-versus-host disease (2015, background): “A pattern of loss of members of Clostridiales, including Roseburia, Faecalibacterium, Ruminococcus and Blautia species, can similarly be observed in volunteers placed on high-protein and low-carbohydrate diets [53] or on diets derived entirely from animal products [54].”
• Formation of propionate and butyrate by the human colonic microbiota. (2017, background): “…to a disproportionate decrease in butyrate among total faecal SCFA, together with an increased proportion of branched chain fatty acids that are wholly derived from branched chain amino acids and therefore provide an indicator of protein fermentation (Duncan et al., 2007, Russell et al., 2011).”
• High-fat diet alters gut microbiota physiology in mice (2013, background): “…Journal in diet-induced obesity (Turnbaugh et al., 2008), evidence from human intervention studies clearly indicates decreased short-chain fatty acids, in particular butyrate, yet increased branchedchain fatty acids concentrations after HF feeding (Brinkworth et al., 2009; Russell et al., 2011).”
• Effects of Gut Microbes on Nutrient Absorption and Energy Regulation (2012, background): “Low carbohydrate accompanied by high protein in the diet led to significant reduction in the Roseburia/E rectale group, which might negatively affect host health by leading to a reduction in butyrate production.(58) As would be expected, the introduction of a diet high in both fat and sugar (ie, Wes”
• Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism (2016, background): “Relatively minor amounts of branched chain fatty acids are also produced, mainly through fermentation of protein-derived branched chain amino acids.(7)”
• Current understanding of dysbiosis in disease in human and animal models (2016, background): “In studies investigating the roles of high-protein/low-carb versus high-protein/moderatecarb diets, the presence of fiber and nondigestible carbohydrates contribute to the prevention of CRC development.(57) This is believed to be in part due to increased SCFA fermentation, which can affect the colon”
• Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans. (2013, background): “Whereas little is known about the functional significance of branched SCFAs, proteolytic products such as hippurate, p-cresyl, ammonia, and phenols as well as sulfide metabolites have been shown to be inflammatory and carcinogenic in experimental models (53, 54).”