An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota

By Ian B. Jeffery, P. O’Toole, L. Öhman, Marcus J. Claesson, J. Deane, E. Quigley, M. Simrén. Gut, 2011

802 citations recorded by the source corpus.

Subfields: Gastroenterology, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7afeac6b96f055582f6b27042e940b6353e3a9c8

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Citations in the corpus

Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine (2014, positive): “Indeed, the gut microbiome of IBS patients is often dominated by Firmicutes (Jeffery et al., 2012), the phylum from which the decarboxylases described here derive, raising the question of whether the bacterial production of tryptamine plays a role in the pathogenesis of IBS.”
Minireview: Gut microbiota: the neglected endocrine organ. (2014, background): “The relevance of these preclinical findings to the clinical situation is probably best gauged from studies in irritable bowel syndrome (IBS), a functional GI disorder that has been linked to alterations in the gut microbiota (140).”
Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Disease (2012, background): “The microbiota of IBS patients compared with controls has a 2-fold increase in the ratio of Firmicutes to Bacteroidetes [133,134].”
Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders (2015, background): “For example, IBS subtypes have been stratified according to their microbiota profiles, specifically those with an increased Firmicutes: Bacteroidetes ratio (Jeffery et al., 2012b).”
Gut microbes promote colonic serotonin production through an effect of short‐chain fatty acids on enterochromaffin cells (2015, background): “In a recent study, a subset of patients with IBS was shown to harbor gut microbiomes characterized by overrepresentationof Firmicutes-associated taxa anddepletion of taxa within phylum Bacteroidetes (33); this study also identified provocative associations between gut microbial taxa and clinical cha”
Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis (2014, background): “The biological basis of IBS is poorly understood though there is evidence for a contribution of genetic risk factors as well as environmental stimuli such as early-life stress (Fukudo & Kanazawa 2011; Mayer et al. 2001).”