Differential Adaptation of Human Gut Microbiota to Bariatric Surgery–Induced Weight Loss
By J. Furet, L. Kong, Julien Tap, C. Poitou, A. Basdevant, J. Bouillot, D. Mariat, G. Corthier, J. Dore, C. Henegar and 2 more. Diabetes, 2010
1,181 citations recorded by the source corpus.
OBJECTIVE Obesity alters gut microbiota ecology and associates with low-grade inflammation in humans. Roux-en-Y gastric bypass (RYGB) surgery is one of the most efficient procedures for the treatment of morbid obesity resulting in drastic weight loss and improvement of metabolic and inflammatory status. We analyzed the impact of RYGB on the modifications of gut microbiota and examined links with adaptations associated with this procedure. RESEARCH DESIGN AND METHODS Gut microbiota was profiled from fecal samples by real-time quantitative PCR in 13 lean control subjects and in 30 obese individuals (with seven type 2 diabetics) explored before (M0), 3 months (M3), and 6 months (M6) after RYGB. RESULTS Four major findings are highlighted: 1) Bacteroides/Prevotella group was lower in obese subjects than in control subjects at M0 and increased at M3. It was negatively correlated with corpulence, but the correlation depended highly on caloric intake; 2) Escherichia coli species increased at M3 and inversely correlated with fat mass and leptin levels independently of changes in food intake; 3) lactic acid bacteria including Lactobacillus/Leuconostoc/Pediococcus group and Bifidobacterium genus decreased at M3; and 4) Faecalibacterium prausnitzii species was lower in subjects with diabetes and associated negatively with inflammatory markers at M0 and throughout the follow-up after surgery independently of changes in food intake. CONCLUSIONS These results suggest that components of the dominant gut microbiota rapidly adapt in a starvation-like situation induced by RYGB while the F. prausnitzii species is directly linked to the reduction in low-grade inflammation state in obesity and diabetes independently of calorie intake.
Subfields: Gastroenterology, Molecular Biology, Surgery
View Paper: https://www.semanticscholar.org/paper/86759b5dfac783f7d6207984b7b58ed67ef5f635
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In Gastroenterology
In Molecular Biology
- F. Bäckhed
- V. Tremaroli
- Tiangang Li
- P. Kovatcheva-Datchary
- M. Ståhlman
- Sander Rensen
- S. Pesoa
- Rosa Krajmalnik-Brown
In Surgery
Citations in the corpus
- The human gut microbiota: Metabolism and perspective in obesity (2018, background): “women,(84,90) children,(91) and infants of normal weight mothers(85); however, this genus was decreased in individuals subjected to RYGB.(88,93) Bifidobacterium species have been shown to deconjugate bile acids, which may decrease fat absorption.”
- Bile Acid Signaling in Metabolic Disease and Drug Therapy (2014, background): “Gastric bypass changes gut microbiota and is associated with weight loss and inflammation (Zhang et al., 2009a; Furet et al., 2010; Graessler et al., 2013).”
- Human Gut Microbiota Changes Reveal the Progression of Glucose Intolerance (2013, methodology): “[39] analyzed the gut microbiota composition in 13 lean individuals and 30 obese subjects, including 7 T2DM patients who underwent a Roux-en-Y gastric bypass.”