Transcriptional regulatory circuits controlling mitochondrial biogenesis and function.

By D. Kelly, R. Scarpulla. Genes & Development, 2004

1,262 citations recorded by the source corpus.

We are witnessing a period of renewed interest in the biology of the mitochondrion. The mitochondrion serves a critical function in the maintenance of cellular energy stores, thermogenesis, and apoptosis. Moreover, alterations in mitochondrial function contribute to several inherited and acquired human diseases and the aging process. This review summarizes our understanding of the transcriptional regulatory mechanisms involved in the biogenesis and energy metabolic function of mitochondria in higher organisms.

Subfields: Cancer Research, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/47fff57b22f913507a50b8fdda42a826c863dceb

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Citations in the corpus

Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network (2010, background): “The two factors frequently work in conjunction in the expression of many nuclear genes specifying essential mitochondrial functions [7,17,18].”
Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha. (2008, background): “The nuclear respiratory factors 1 and 2 have been linked to the transcriptional control of many mitochondrial genes whose list has expanded greatly in the last few years (see Table 1 in Kelly and Scarpulla 10 ).”
Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. (2011, background): “Other interesting TFEB targets are peroxisome proliferatoractivated receptor-gamma coactivator-1a, which is involved in mitochondrial biogenesis and the insulin signaling pathway (1,53,54), PRKAG2, a member of the AMPK (MAP kinase) gamma subunit family involved in the regulation of the synthesis of ”
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. (2007, background): “…nuclear respiratory factor 1 (NRF-1), GA binding proteins (GABP a , GABP b 2), peroxisome proliferator-activated receptors (PPAR-a , PPAR-g ), PPAR-g coactivators (PGC-1 a , PGC-1 b ), PGC-1-related coactivator 1 (PPRC1), and C-MYC (Kelly and Scarpulla, 2004; Bogacka et al., 2005; Li et al., 2005).”
Mitochondrial fragmentation in neurodegeneration (2008, background): “Peroxisome proliferator-activated receptor-γ co-activator-1α ( PGC1α ) is a transcriptional co-activator that is a master regulator of mitochondrial biogenesis and respiratio”
Myc Stimulates Nuclearly Encoded Mitochondrial Genes and Mitochondrial Biogenesis (2005, background): “NRF1 is a major transcriptional regulator of mitochondrial biogenesis and recently has been thought to collaborate with E2F, although TFAM was found bound by NRF1 but not E2F (5, 25).”
Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF (2013, positive): “…factor 1 (NRF1), GA binding proteins (GABPA,GABPB2), peroxisome proliferator-activated receptors 304 Cancer Cell 23, 302–315, March 18, 2013 ª2013 Elsevier Inc. (PPARa, PPARb), PPAR-g coactivators (PGC1a, PGC1b), and PGC1-related coactivator 1 (PPRC1) (reviewed in Kelly and Scarpulla, 2004).”
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. (2006, background): “PGC-1a has emerged as a master regulator of mitochondrial biogenesis and respiration (Kelly and Scarpulla, 2004; Lehman et al., 2000; Lin et al., 2002; Puigserver et al., 1998; Wu et al., 1999).”
A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine (2005, background): “ATP synthase β subunit (ATPsynβ) and cytochrome c (cytc) and the mtTFA, which regulates mtDNA transcription (92, 196).”
Integrative biology of exercise. (2014, positive): “…mitochondrial biogenesis, including the estrogen-receptor-related receptors (ERR) a and d and the peroxisome proliferator-activated receptor coactivators (PPARs), which regulate expression of the mitochondrial fatty acid oxidative enzymes (Kelly and Scarpulla, 2004; Scar-pulla, 2006).”
Sirtuin Regulation of Mitochondria - Energy Production, Apoptosis, and Signaling (2010, background): “The transcriptional coactivator PGC-1α, a master regulator of mitochondrial biogenesis and function, is responsive to a variety of metabolic stresses, ensuring that the number and capacity of mitochondria keeps pace with the energetic demands of tissues [7].”
PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress (2013, positive): “A Subset of Human Melanoma Tumors Expresses High Levels of PGC1a and Mitochondrial Genes of Oxidative Metabolism Given the central role of PGC1a in oxidative metabolism and ROS detoxification in a variety of tissues (Puigserver and Spiegelman, 2003; Kelly and Scarpulla, 2004; Fernandez-Marcos and Au”
Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. (2006, background): “, 2004) and nuclear respiratory factors (NRF) 1 and 2 (Kelly and Scarpulla, 2004; Puigserver and Spiegelman, 2003; Wu et al., 1999a).”
Mitochondrial Dysfunction in Neurodegenerative Diseases (2012, background): “We showed a pathologic grade-dependent significant reduction in numbers of mitochondria in striatal spiny neurons, which correlated with reductions in PGC-1␣ and Tfam (Kim et al., 2010).”