Mitochondrial fragmentation in neurodegeneration

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Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences (2012, neutral): “Beyond any doubt, dysregulation of mitochondrial dynamics can cause or at least contribute to the pathogenesis of various neurological disorders (reviewed in Chan, 2006; Knott et al , 2008; Oettinghaus et al , 2012; and Pilsl and Winklhofer, 2012).”
Mitochondrial fusion and fission in cell life and death (2010, background): “Mitochondrial dynamics in human disease Defects in mitochondrial fusion and fission primarily affect neuronal functions, as nerve cells have a high energy demand and strictly depend on mitochondrial functions, and neurons are particularly sensitive to perturbations of mitochondrial distributio”
Multiple Functions of BCL-2 Family Proteins (2013, neutral): “3) (Frank 2006; Detmer and Chan 2007; Knott et al. 2008).”
Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease (2013, neutral): “…ﬁ ssion and fusion are regulated by mitochondrial ﬁ ssion proteins such as dynamin-like protein 1 protein (DLP1, also referred to as DRP1), Fis1 [114,115], and Mff [116], and mito-chondrialfusionproteinssuchasmitofusin1(Mfn1),mitofusin2(Mfn2), and optic atrophy protein 1 (OPA1) [114,115].”