Integrative biology of exercise.
By J. Hawley, M. Hargreaves, Michael J. Joyner, J. Zierath. Cell, 2014
983 citations recorded by the source corpus.
Exercise represents a major challenge to whole-body homeostasis provoking widespread perturbations in numerous cells, tissues, and organs that are caused by or are a response to the increased metabolic activity of contracting skeletal muscles. To meet this challenge, multiple integrated and often redundant responses operate to blunt the homeostatic threats generated by exercise-induced increases in muscle energy and oxygen demand. The application of molecular techniques to exercise biology has provided greater understanding of the multiplicity and complexity of cellular networks involved in exercise responses, and recent discoveries offer perspectives on the mechanisms by which muscle "communicates" with other organs and mediates the beneficial effects of exercise on health and performance.
Subfields: Cell Biology, Physiology, Rehabilitation
View Paper: https://www.semanticscholar.org/paper/dfa8567f7211fdc4d53335ba0f079c5d64fa8050
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Citations in the corpus
- Physiological adaptations to interval training and the role of exercise intensity (2017, background): “The molecular and cellular events that underpin adaptations to exercise are fundamental aspects of exercise biology (Egan & Zierath, 2013; Hawley et al. 2014), and the responsiveness of these pathways to divergent exercise stimuli is essential for understanding the process through which humans…”
- Metabolic flexibility in health and disease (2017, neutral): “Although the topic of exercise-induced changes in metabolism has been covered in recent reviews (see Egan and Zierath, 2013; Hawley et al., 2014), themechanisms underlyingmetabolic flexibility with exercise deserve further inquiry.”
- Vascular Adaptation to Exercise in Humans: Role of Hemodynamic Stimuli. (2017, background): “Exercise increases systolic pressure, whilst diastolic pressures remain at resting levels or may decrease (127).”