Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation.

By Marc Uldry, Wenli Yang, J. St-Pierre, Jiandie D. Lin, P. Seale, B. Spiegelman. Cell Metabolism, 2006

667 citations recorded by the source corpus.

Subfields: Biochemistry, Nutrition and Dietetics, Physiology

View Paper: https://www.semanticscholar.org/paper/5486cabec34c3024ee0cdb3e3df9b4775ad51951

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. B. Spiegelman
2. E. Rosen
3. R. Scarpulla
4. Y. Tseng
5. C. V. Dang
6. C. R. Kahn
7. S. Gesta
8. S. Farmer

In Nutrition and Dietetics

1. C. V. Dang
2. G. Semenza
3. S. Kajimura

In Physiology

1. B. Spiegelman
2. S. Kajimura
3. R. Scarpulla
4. E. Rosen
5. P. Seale
6. Christoph Handschin
7. Jiandie D. Lin
8. Y. Tseng

Citations in the corpus

• Developmental origin of fat: tracking obesity to its source. (2007, positive): “Brown preadipocytes lacking PGC-1α show reduced induction of thermogenic genes but differentiate normally, suggesting that PGC-1α is important for the thermogenic function of brown fat but is dispensable for induction of lipid accumulation (Uldry et al., 2006).”
• HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. (2007, methodology): “PGC-1b mRNA Expression Is Regulated by the VHL/HIF-1/C-MYC Pathway To search for a factor that functions in the mitochondrial biogenesis pathway downstream of C-MYC, we performed qrtPCR to analyze the expression of mRNAs encoding mitochondrial RNA polymerase (POLRMT) and 11 transcription factors (GA”
• Adaptive thermogenesis in adipocytes: is beige the new brown? (2013, background): “However, PGC-1a-null brown adipocytes differentiate normally without alteration in numerous brown fatselective genes, indicating that it is not a determinant of brown adipocyte identity per se (Uldry et al. 2006).”
• Transcriptional control of adipocyte formation. (2006, background): “During development, PGC-1a and b regulate brown adipose formation by coactivating transcription factors including nuclear respiratory factor 1 (NRF-1) and PPARg that regulate thermogenesis and mitochondrial biogenesis (Lin et al., 2005; Uldry et al., 2006).”
• Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. (2006, background): “PGC-1a Null Cells Display a Blunted Induction of the ROS Defense System and Are More Sensitive to Oxidative Stress We have also examined the response to H2O2 in brown-fat fibroblasts genetically deficient in PGC-1a (Uldry et al., 2006).”
• Transcriptional control of mitochondrial biogenesis and function. (2009, background): “PGC-1α also induces deiodinase 2, which generates local thyroid hormone and further enhances mitochondrial function (112).”
• Transcriptional control of brown fat determination by PRDM16. (2007, background): “However, it is notable that shRNAmediated suppression of PGC-1β in the cells lacking PGC-1α caused a further loss of the brown fat phenotype (Uldry et al., 2006).”
• Adipocytes as regulators of energy balance and glucose homeostasis (2006, background): “Although PGC-1α is clearly a key effector of the thermogenic programme of brown fat, cells lacking PGC-1α still show a morphology that is brown-fat-like, and still express certain molecular markers of brown fa”
• Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF (2013, neutral): “PGC1b shares significant sequence homology and functional overlap with PGC1a, including the activation of mitochondrial biogenesis and oxidative phosphorylation, but also has several distinct functions in different tissues (Lin et al., 2005b; Uldry et al., 2006; Wolfrum and Stoffel, 2006).”
• Forming functional fat: a growing understanding of adipocyte differentiation (2011, background): “Although PGC1α and the related protein PGC1β do not have significant roles in brown adipogenesis, they are required to maintain the expression of thermogenic genes in mature brown adipocyte”
• Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network (2010, background): “abolished the increase in mitochondrial number and function upon brown fat differentiation [76].”
• Transcriptional paradigms in mammalian mitochondrial biogenesis and function. (2008, background): “This issue was addressed by knocking down the expression of PGC-1 by shRNA in a preadipocyte cell line derived from PGC-1 knockout mice (216).”