Sirtuin Regulation of Mitochondria - Energy Production, Apoptosis, and Signaling

By E. Verdin, M. Hirschey, Lydia W. S. Finley, M. Haigis. TIBS -Trends in Biochemical Sciences. Regular ed, 2010

657 citations recorded by the source corpus.

Sirtuins are a highly conserved family of proteins whose activity can extend lifespan in model organisms such as yeast, worms, and flies. Mammals contain seven sirtuins (SIRT1-7) that modulate distinct metabolic and stress response pathways. Three sirtuins, SIRT3, SIRT4 and SIRT5, are located in the mitochondrion, a dynamic organelle that functions as the primary site of oxidative metabolism and plays critical roles in apoptosis and intracellular signaling. Recent findings have shed light on how the mitochondrial sirtuins function in the control of basic mitochondrial biology, including energy production, metabolism, apoptosis, and intracellular signaling.

Subfields: Geriatrics and Gerontology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/8276a04faae4a5dbb9cd1befbb9a120323440507

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Geriatrics and Gerontology

1. Johan Auwerx
2. C. Cantó
3. M. Haigis
4. Keir J. Menzies
5. L. Guarente
6. S. McKnight
7. W. Kaelin
8. Hung-Chun Chang

In Molecular Biology

1. W. Kaelin
2. Johan Auwerx
3. S. McKnight
4. M. Haigis
5. L. Guarente
6. Arkaitz Carracedo
7. C. Cantó
8. P. Pandolfi

In Physiology

1. Johan Auwerx
2. C. Cantó
3. W. Kaelin
4. Keir J. Menzies
5. M. Haigis
6. S. McKnight
7. L. Guarente
8. Hung-Chun Chang

Citations in the corpus

• SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization (2011, background): “Because SIRT3 activates enzymes involved in mitochondrial fuel catabolism (Verdin et al., 2010), and SIRT3 loss increases glucose uptake (Kim et al., 2010), we hypothesized that SIRT3 could serve as an important regulator of the balance between glycolytic and anabolic pathways and mitochondrial…”
• Influence of Metabolism on Epigenetics and Disease (2013, positive): “The latter proteins are members of the sirtuin family of deacetylases (Figure 1), which include two isoforms that are primarily housed in the nuclei of mammalian cells (SIRT6 and SIRT7), three that are localized to mitochondria (SIRT3, SIRT4, and SIRT5), and two that are found in both cytoplasmic an”
• Lysine Glutarylation Is a Protein Post-Translational Modification Regulated by SIRT5 (2014, background): “Lysine acetylation levels are coupled to metabolism and play key roles in regulating mitochondrial enzymes, chromatin biology, and other cellular processes (Chalkiadaki andGuarente, 2012; Verdin et al., 2010; Xiong and Guan, 2012).”
• Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging (2011, background): “However, it is clear that the decline of the integrity of mitochondria as a function of age is implicated in aging and agerelated diseases [147].”
• SIRT1 and other sirtuins in Metabolism (2013, background): “SIRT3, SIRT4 and SIRT5 are localized in mitochondria, and regulate the activities of metabolic enzymes and moderate oxidative stress in this organelle [18].”
• Alternative Oxidase: A Mitochondrial Respiratory Pathway to Maintain Metabolic and Signaling Homeostasis during Abiotic and Biotic Stress in Plants (2013, background): “This post-translational control of target protein function is thought to act as a signal, linking mitochondrial metabolism (via NAD level) to events such as changes in gene expression [136].”
• NAD+ metabolism and the control of energy homeostasis - a balancing act between mitochondria and the nucleus (2015, background): “Three sirtuins are located in the mitochondria (SIRT3–SIRT5), while SIRT1, SIRT6 and SIRT7 are predominantly located in the nucleus, and SIRT2 is found in the cytoplasm (Michishita et al., 2005; Verdin et al., 2010).”