Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

By R. Scarpulla. Biochimica et Biophysica Acta, 2010

1,220 citations recorded by the source corpus.

The PGC-1 family of regulated coactivators, consisting of PGC-1α, PGC-1β and PRC, plays a central role in a regulatory network governing the transcriptional control of mitochondrial biogenesis and respiratory function. These coactivators target multiple transcription factors including NRF-1, NRF-2 and the orphan nuclear hormone receptor, ERRα, among others. In addition, they themselves are the targets of coactivator and co-repressor complexes that regulate gene expression through chromatin remodeling. The expression of PGC-1 family members is modulated by extracellular signals controlling metabolism, differentiation or cell growth and in some cases their activities are known to be regulated by post-translational modification by the energy sensors, AMPK and SIRT1. Recent gene knockout and silencing studies of many members of the PGC-1 network have revealed phenotypes of wide ranging severity suggestive of complex compensatory interactions or broadly integrative functions that are not exclusive to mitochondrial biogenesis. The results point to a central role for the PGC-1 family in integrating mitochondrial biogenesis and energy production with many diverse cellular functions.

Subfields: Geriatrics and Gerontology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/6ebc9c4ab79b8d30ac5ae8476122c898e898599c

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Citations in the corpus

Mitochondrial dysfunction in cell senescence and aging (2022, background): “The PPARγ coactivator 1 (PGC-1) family, comprising PGC-1α, PGC-1β, and PGC-1–related coactivator, are main regulators of mitochondrial biogenesis (63).”
PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress (2013, neutral): “Because several transcription factors, including nuclear respiratory factors, ERRs, and YY1 (Scarpulla, 2011; Knutti and Kralli, 2001; Cunningham et al., 2007), control PGC1a function, future studies will focus to assess which transcription factor(s) partners with PGC1a to control mitochondrial func”
Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences (2012, neutral): “…potential, and respiration defects (Exner et al , 2007; Hoepken et al , 2007; Gautier et al , 2008; Piccoli et al , 2008; Dagda et al , 2009, 2011; Gegg et al , 2009; Gispert et al , 2009; Lutz et al , 2009; Sandebring et al , 2009; Cui et al , 2010; Yuan et al , 2010; Amo et al , 2011;…”
The emerging role of Nrf2 in mitochondrial function (2015, background): “The second class of nuclear transcriptional regulators with critical functions in mitochondrial biogenesis are transcriptional coactivators, such as peroxisome proliferator-activated receptor γ coactivators (PGC)1α and 1β, which interact with transcription factors, the basal transcriptional and RNA-”
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function (2012, background): “, 2005), a master regulator of mitochondrial biogenesis that coactivates the nuclear respiratory factors (NRF-1 and NRF-2), which induce the transcription of genes involved in mitochondrial biogenesis (Scarpulla, 2011).”