Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways.

By M. Palmieri, S. Impey, Hyojin Kang, Alberto di Ronza, C. Pelz, Marco Sardiello, Andrea Ballabio. Human Molecular Genetics, 2011

942 citations recorded by the source corpus.

Subfields: Cell Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/6588370b2ec51f7b656e88174a099cd4cd87d2bd

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Citations in the corpus

The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction. (2012, positive): “phagosomal pathways is controlled by transcription factor EB (TFEB), which regulates the expression of 471 genes that constitute the CLEAR (coordinated lysosomal expression and regulation) gene network (Sardiello et al., 2009; Palmieri et al., 2011).”
Endocytosis, Signaling, and Beyond (2014, background): “The CLEAR network contains not only lysosomal proteins but also autophagy substrates (Palmieri et al. 2011).”
The lysosome: from waste bag to potential therapeutic target. (2013, background): “There are 500 direct TFEB target genes, including genes involved in lysosomal biogenesis and autophagy (Palmieri et al., 2011; Settembre et al., 2011).”
TFEB at a glance (2016, background): “TFEB has been shown to directly bind to CLEAR elements, thereby promoting the expression of the entire network of genes that contains the CLEAR regulatory motif in their promoter (namely the CLEAR network) (Palmieri et al., 2011; Sardiello et al., 2009).”
Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance (2011, background): “In a separate study, we demonstrated that the gene encoding MCOLN1 is regulated by TFEB (Palmieri et al., 2011), making it an appealing candidate to mediate TFEB effects”
MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB (2012, background): “Finally, it is important to keep in mind that TFEB does not only activate autophagy genes but also genes involved in lysosomal biogenesis, regulation of endo- and exocytosis, and expression of nonlysosomal enzymes implicated in the degradation of essential proteins.(12) Therefore, in agreement with ”
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB (2012, background): “The expression of several lysosomal/autophagic genes that were shown to be targets of TFEB (Palmieri et al , 2011) was tested in primary hepatocytes from a conditional knockout mouse line in which TFEB was deleted in the liver ( Tcfeb ﬂox/ﬂox; alb-CRE), and in a control mouse line ( Tcfeb ﬂox/ﬂox).”
From Krebs to Clinic: Glutamine Metabolism to Cancer Therapy (2016, neutral): “BPTES inhibition of hGA(124-551), a truncated form of human kidneytype glutaminase.”
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, positive): “some and autophagosome biogenesis was identified using a systems-biology approach.(625,635,636) The basic helix-loophelix transcription factor TFEB acts as a master gene of the”
Regulation of mTORC1 and its impact on gene expression at a glance (2013, background): “In response to starvation or lysosomal dysfunction, TFEB positively regulates the expression of lysosomal hydrolases, lysosomal membrane proteins and components of the v-ATPase complex (Palmieri et al., 2011).”