Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators.

By J. St-Pierre, S. Drori, Marc Uldry, Jessica M. Silvaggi, James Rhee, Sibylle Jäger, Christoph Handschin, Kangni Zheng, Jiandie D. Lin, Wenli Yang and 3 more. Cell, 2006

2,264 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/b9dc0326f81b07ed23eb69c5e06f4255f1022529

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Citations in the corpus

The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. (2010, background): “Additionally, SIRT1 action prevents oxidative damage in the pancreas, not only by decreasing the production of reactive oxygen species in the mitochondria, but also by enhancing FOXO and PGC-1 -mediated transcription of detoxification genes (111, 112).”
Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis (2010, background): “Another study demonstrated that PGC-1a suppresses ROS production through the induction of ROS-detoxifying enzymes [14].”
Signal transduction by reactive oxygen species (2011, background): “Interestingly, PGC-1 appears to regulate new mitochondrial formation while simultaneously regulating antioxidant expression (St-Pierre et al., 2006).”
13 reasons why the brain is susceptible to oxidative stress (2018, background): “If mutant mitochondria accumulate, they may cause dysfunction by clonal expanding their number because O2/H2O2 regulate mitochondrial biogenesis [111,122,123].”
Mitochondrial fragmentation in neurodegeneration (2008, background): “Peroxisome proliferator-activated receptor-γ co-activator-1α ( PGC1α ) is a transcriptional co-activator that is a master regulator of mitochondrial biogenesis and respiratio”
Biological markers of oxidative stress: Applications to cardiovascular research and practice (2013, positive): “Additional examples include peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1 α ) [88] and the thioredoxin family as reviewed by Lee and colleagues [89].”
Oxidative Stress in Cancer (2020, background): “It increases oxidative phosphorylation by activating PPARγ and nuclear respiratory factors 1 and 2, and also increases antioxidant capacity (Table 1) as well as decreasing mitochondrial production of ROS by activating uncoupling protein-1 and −2, and stimulating mitochondrial biogenesis (Guo et al.,”
PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism (2020, background): “SIRT3 overexpression might stimulate FOXO3a deacetylation and, consequently, PGC-1α and MnSOD upregulation, which enables ROS detoxification and improves insulin sensitivity [190].”
Skeletal muscle fatigue: cellular mechanisms. (2008, background): “Furthermore, a recent study showed that PPAR coactivator 1 , which is a potent stimulator of mitochondrial biogenesis, has a central role in the induction of several ROS defense enzymes in response to oxidative stress (419).”
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway (2013, background): “PGC-1a has been shown to be neuroprotective in the MPTP mouse model of Parkinson's disease (St-Pierre et al., 2006).”