Natural versus adaptive regulatory T cells.

By L. Cassis, S. Aiello, M. Noris. Contributions to Nephrology, 2005

1,037 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/3b3b3de79a0b6902a4594600cf22a2e4b2d47104

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In Immunology

1. D. Munn
2. A. Mellor
3. V. Kuchroo
4. H. Hammad
5. B. Lambrecht
6. Y. Belkaid
7. C. Serhan
8. T. Korn

Citations in the corpus

• Natural regulatory T cells in infectious disease (2005, background): “Indeed, it is has been conceded that several types of regulatory cells exist, some of which are induced in response to infectious challenge and some that are considered natural regulator”
• Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3 (2003, background): “Of many unresolved questions regarding Treg, where and how they are generated remains significant (2, 33).”
• Regulatory T cells: friend or foe in immunity to infection? (2004, background): “It seems that natural self-antigen-reactive CD4 + CD25 + T Reg cells develop in the thymus and then enter peripheral tissues, where they suppress the activation of other self-reactive T cell”
• Ido expression by dendritic cells: tolerance and tryptophan catabolism (2004, background): “We think it is unlikely that IDO participates in development of the self-directed T Reg cells that arise in the thymu”
• Modulation of tryptophan catabolism by regulatory T cells (2003, background): “It has become increasingly apparent that these cells not only exist as natural and adaptive subsets that contribute to the maintenance of self-toleranc”
• Interleukin-35-mediated induction of a novel regulatory T cell population (2010, neutral): “Induced regulatory T cells (iT R cells) can be generated in the periphery or in vitro from conventional CD4 + Foxp3 − T cells (T conv cells”
• Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases. (2004, background): “Recently it has been demonstrated that regulatory T (Treg) cells have a role in the induction of transplantation tolerance (Graca et al., 2002; Karim et al., 2002; Bach, 2003; Bluestone and Abbans, 2003; Word and Sakaguchi, 2003).”
• Pro-Resolving lipid mediators and Mechanisms in the resolution of acute inflammation (2014, background): “The former arises during the normal process of maturation in the thymus, the latter developing from conventional CD4+CD25− T-cells in the periphery under specific stimulatory conditions elicited by infection and collateral tissue damage (Bluestone and Abbas, 2003).”
• Essential Role of Lung Plasmacytoid Dendritic Cells in Preventing Asthmatic Reactions to Harmless Inhaled Antigen (2004, background): “In this scenario, in the absence of pDCs, T reg cells would no longer be induced from naive T cells or expanded from a pool of naturally occurring OVA-responsive CD4 CD25 regulatory cells (44, 45).”
• CD4+CD25−Foxp3− Th1 cells are the source of IL-10–mediated immune suppression in chronic cutaneous leishmaniasis (2007, background): “settings involving high- versus low-level infl ammation, respectively (23, 42).”
• Immune Regulation by helminth parasites: cellular and molecular mechanisms (2003, background): “The general concept for T Reg cells has been that they are autoreactive thymic emigrants, otherwise known as 'natural' T Reg cell”
• Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells (2004, background): “The concept of “natural” and “adaptive” regulators proposed recently (11) addresses the diversity of Tregs with respect to function and development.”
• Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation (2007, background): “T-reg expand from natural T-reg in autoimmune inflammation T-reg not only occur as thymus-derived natural T-reg but can be induced upon encounter of T cells with antigen in a specific cytokine milie”
• The Foxp3+ regulatory T cell: a jack of all trades, master of regulation (2008, background): “T reg cells can also be induced from naive T cells in the peripher”
• The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells1 (2006, background): “We found that mature peripheral CD4 CD25 T cells, that are relatively resistant to CD3 down-regulation by LT-K, can indeed convert to a CD4 CD25 Treg phenotype through a process requiring GCN2 and leading to a gradual decrease in IL-2 production and up-regulation of IL-10 and TGF- .”
• CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells (2006, background): “This so-called “adaptive” T reg cell population shares many of the attributes of thymic-dependent, natural T reg cells, but can diff er in critical cell surface biomarkers and functional attributes (12).”