The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells1

By Francesca Fallarino, U. Grohmann, S. You, Barbara C. McGrath, D. Cavener, C. Vacca, C. Orabona, R. Bianchi, M. L. Belladonna, C. Volpi and 3 more. Journal of Immunology, 2006

1,087 citations recorded by the source corpus.

Subfields: Genetics, Immunology

View Paper: https://www.semanticscholar.org/paper/46675fe91419f343a552adf4720cd09e365e70a6

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In Genetics

1. D. Munn
2. A. Mellor
3. Cristina Gutiérrez-Vázquez
4. J. Rathmell

In Immunology

1. D. Munn
2. A. Mellor
3. V. Bronte
4. Paola Zanovello
5. P. Serafini
6. James P. Allison
7. J. Wolchok
8. L. Dolcetti

Citations in the corpus

• Molecular Mechanisms of Treg-Mediated T Cell Suppression (2012, background): “At the same time, IDO leads to iTreg generation (Fallarino et al., 2003, 2006; Curti et al., 2007).”
• Indoleamine 2,3 dioxygenase and metabolic control of immune responses (2012, background): “59 Fallarino, F. et al. (2003) Modulation of tryptophan catabolism by regulatory T cells.”
• Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism (2010, background): “Trp starvation and kynurenines were previously shown to convert naive T cells into Treg cells, which help to prevent autoimmune disease (29, 44).”
• IDO in the Tumor Microenvironment: Inflammation, Counter-regulation and Tolerance (2016, positive): “The AhR can promote Treg cell differentiation [29, 30], and can also bias dendritic cells (DCs) and macrophages toward an immunosuppressive phenotype [6, 31-33].”
• Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy. (2020, background): “A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript accumulation of MDSCs and inhibiting T cell function (Raber, Ochoa, & Rodríguez, 2012).”
• Regulation of the immune response by the aryl hydrocarbon receptor (2018, background): “IDO1 and IDO2 catalyze Kyn production, which boosts FoxP3+ Treg cell differentiation (Fallarino et al., 2006).”
• Tumor‐induced tolerance and immune suppression by myeloid derived suppressor cells (2008, background): “Indoleamine 2,3dioxygenase L-tryptophan L-tryptophan depletion and kinurenine production IFN-g Plasmacytoid DC, MØ, DC subsets Downregulation of z chain of CD3 complex (160)”
• Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase. (2007, methodology): “Recently it has been shown that IDO can bias naive CD4+ T cells to differentiate into Foxp3+ Tregs in vitro (11).”