Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation

By T. Korn, J. Reddy, Wenda Gao, E. Bettelli, A. Awasthi, T. Petersen, B. Bäckström, R. Sobel, K. Wucherpfennig, T. Strom and 2 more. Nature Medicine, 2007

887 citations recorded by the source corpus.

Subfields: Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/f405ff9021d92b19c69769fdf974081dc5cd59f7

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Citations in the corpus

Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. (2008, neutral): “Because some nTreg cells are reactive with MOG peptides (Korn et al., 2007), the recipients were immunized with MOG peptide in CFA.”
A dominant function for interleukin 27 in generating interleukin 10–producing anti-inflammatory T cells (2007, background): “In addition, the therapeutic efficacy of the Foxp3 + T reg cells is compromised in the presence of inflammatory cytokines because effector T cells may become refractory to Foxp3 + T reg cell–mediated suppressio”
Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. (2008, background): “However, although CD4 FoxP3 regulatory T cells are present in the CNS during EAE, they are unable to contain the inflammatory damage.(10) In addition, IL-17 has been implicated not only in the animal model for MS, but also in various disease models for other autoimmune diseases, such as rheumatoid a”
Multiple sclerosis: a complicated picture of autoimmunity (2007, background): “In EAE, T reg cells have been shown to migrate into the lesion, but they seem ineffectual in moderating disease produced by T H -17 cell”
Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases (2010, neutral): “), in experimental autoimmune encephalomyelitis (EAE”
The PD-1 Pathway in Tolerance and Autoimmunity (2010, background): “During EAE, an accumulation of Tregs in the CNS has consistently been seen during disease resolution (129, 161, 165, 166).”
Normalization of Obesity-Associated Insulin Resistance through Immunotherapy: CD4+ T Cells Control Glucose Homeostasis (2009, background): “It is also possible that T regulatory cell function may be suboptimal in the inflammatory VAT environment, as suggested in autoimmune disease model”
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells (2012, methodology): “A previous study used an EAE model induced by MOG immunization with CFA and pertussis toxin; in this study, conversion of naive T cells into iT reg cells was not observed (Korn et al., 2007).”
Regulation of the immune response by the aryl hydrocarbon receptor (2018, background): “AhR synergizes with cMaf to drive the expression of IL-10 and IL-21 in Tr1 cells (Apetoh et al., 2010; Gandhi et al., 2010; Wu et al., 2011).”
Regulatory T cells exert checks and balances on self tolerance and autoimmunity (2010, background): “For example, immunizing mice with myelin basic protein (MBP) in CFA expands MBP-specific Foxp3 + T reg cell populations in the EAE lesion”