The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

By Q. Tang, J. Bluestone. Nature Immunology, 2008

1,095 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/92e2754e6de94fdcff70d969f732b015595f89a6

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Citations in the corpus

Foxp3 instability leads to the generation of pathogenic memory T cells in vivo (2009, neutral): “5 mice and expanded each population in vitro with IL-2 and beads coated with antibody to CD3 (anti-CD3) plus anti-CD28 (ref”
CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients. (2010, background): “However, upregulation of CD80 and CD86 in response to (C) Representative dot plot showing the frequency of CD19+CD24hiCD38hi, CD19 one SLE patient.”
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells (2009, background): “…3015-3029 www.jem.org/cgi/doi/10.1084/jem.20090847 3015 Regulatory T (T reg) cells are key mediators of peripheral tolerance that actively suppress e ec- tor T (T e ) cells and inhibit immune-mediated tissue damage (Kronenberg and Rudensky, 2005; Sakaguchi et al., 2008; Tang and Bluestone, 2008).”
Inflammatory mechanisms in ischemic stroke: role of inflammatory cells (2010, neutral): “at the site of inflammation [96].”
Categorical Analysis of Human T Cell Heterogeneity with One-Dimensional Soli-Expression by Nonlinear Stochastic Embedding (2016, methodology): “For instance, Treg-like subset 4 expressed FOXP3 lo CD127 lo CD39 + CTLA-4 + , with four subpopulations separated by their various expressions of IL-2, TNF-a , and CLA.”
The X-files in immunity: sex-based differences predispose immune responses (2008, background): “T Reg cells regulate the size of the peripheral T-cell pool, modulate immune responses to infection and participate in the maintenance of self-tolerance by suppressing immune responses mediated by autoreactive T cells that can contribute to autoimmune disease 21 .”
Molecular Mechanisms of Treg-Mediated T Cell Suppression (2012, methodology): “SUPPRESSION OF PROLIFERATION VERSUS CYTOKINE PRODUCTION – DIFFERENT MECHANISMS? As suggested by others (Tang and Bluestone, 2008), we propose that different mechanisms of suppression might be used by Tregs depending on their activation state, the site of inflammation, effector cell types and point i”