Modulation of tryptophan catabolism by regulatory T cells

By Francesca Fallarino, U. Grohmann, K. Hwang, C. Orabona, C. Vacca, R. Bianchi, M. L. Belladonna, M. Fioretti, M. Alegre, Paolo Puccetti. Nature Immunology, 2003

1,494 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/d82461ce91940fe2870a201864366be7490992fa

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Citations in the corpus

How regulatory T cells work (2008, background): “Importantly, it was also shown that T Reg cells could condition DCs to express indoleamine 2,3-dioxygenase ( IDO ), a potent regulatory molecule which is known to induce the production of pro-apoptotic metabolites from the catabolism of tryptophan, resulting in the suppression of effector T cells t”
T Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis (2012, positive): “Our recent discovery that Tregs secrete VEGF (3), a known immunosuppressive molecule, adds to the panel of paracrine mechanisms through which Treg can exert suppression and affect the differentiation and function of DCs.”
Ido expression by dendritic cells: tolerance and tryptophan catabolism (2004, background): “This role for CD80/CD86 molecules has subsequently been confirmed in both mouse and human DCs in several model system”
Co-inhibitory molecules of the B7–CD28 family in the control of T-cell immunity (2004, background): “Two recent studies provide a new explanation and highlight the importance of CD80/CD86 reverse signallin”
The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells (2009, background): “CD28 on T cell surfaces interacts with B7 molecules on DCs and promotes T cell activation, whereas the interaction of CTLA-4 with B7 induces expression of indoleamine 2,3-deoxygenase and shuts down immune reaction”
Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase. (2007, background): “CTLA4 has multiple regulatory roles in the immune system, most of which are intrinsic to the CTLA4+ T cells themselves; however, it is also known that CTLA4 can induce IDO expression in DCs, via back-signaling through B7 molecules (27).”
Indoleamine 2,3 dioxygenase and metabolic control of immune responses (2012, background): “10, 504–513 61 Jia, L. et al. (2008) Toxicology and pharmacokinetics of 1-methyl-dtryptophan: absence of toxicity due to saturating absorption.”
Indoleamine 2,3-dioxygenase and tumor-induced tolerance. (2007, background): “Grohmann and colleagues showed that Tregs can trigger high levels of functional IDO expression in mouse DCs in vitro (80).”
Immunostimulatory monoclonal antibodies for cancer therapy (2007, background): “It is possible that CTLA-4 expressed by T Reg cells is involved in inducing tolerance in CD80-expressing DCs owing to reverse signallin”