Ido expression by dendritic cells: tolerance and tryptophan catabolism

By A. Mellor, D. Munn. Nature reviews. Immunology, 2004

2,452 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Immunology

View Paper: https://www.semanticscholar.org/paper/6d33cc25f45a83fd99c62747e961050b851cfe36

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biological Psychiatry

1. D. Munn
2. A. Mellor
3. W. Zou
4. G. Dranoff
5. George Coukos
6. Augusto Ochoa
7. P. Rodriguez
8. I. Mellman

In Immunology

1. D. Munn
2. A. Mellor
3. Shimon Sakaguchi
4. W. Zou
5. E. Wherry
6. V. Kuchroo
7. Y. Belkaid
8. George Coukos

Citations in the corpus

• Mesenchymal stem cells avoid allogeneic rejection (2005, background): “Indoleamine 2,3-dioxygenase (IDO) is an enzyme that catabolizes L-Tryptophan, thereby depleting an essential amino acid from the local environment [86-89].”
• Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism (2010, background): “IDO DC play an important role in immune tolerance, a process that involves Treg cell development (20, 21).”
• T cell exhaustion (2011, background): “or altered antigen-presenting cells, such as those that produce the suppressive enzyme ID”
• Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1 (2009, result): “This hypothesis is compatible with previous studies showing that the proinflammatory cytokines IL-1 or TNF- can significantly enhance IFN-–dependent indoleamine 2,3-dioxygenase expression on epithelial cells (35, 36).”
• Mechanisms of suppression by suppressor T cells (2005, background): “Reduced amounts of free tryptophan after induction of IDO are associated with decreased activation of T cells and thus this would represent an APC-dependent mechanism of in vitro suppressio”
• Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders (2010, background): “iDO DCs promote the development of Treg cells (23).”
• Indoleamine 2,3-dioxygenase and tumor-induced tolerance. (2007, background): “In addition to TLR ligands, IDO is known to be inducible by IFN-γ and IFN-α , one or both of which are frequently found at sites of inflammation (118) .”
• CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms (2004, background): “For example, it has been shown that CTLA-4–B7 interactions lead to the induction of indoleamine 2,3-dioxygenase in tolergenic dendritic cell (DC) populations (42, 44).”
• The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells1 (2006, background): “T he immunoregulatory enzyme IDO mediates conversion of the essential amino acid tryptophan to metabolic byproducts collectively known as kynurenines (1, 2).”
• Regulatory T cells, tumour immunity and immunotherapy (2006, background): “IDO + human APCs reduce tryptophan, and suppress T-cell activation and promote tolerance in the tumour microenvironmen”