Interleukin-35-mediated induction of a novel regulatory T cell population
By L. Collison, Vandana Chaturvedi, Abigail L. Henderson, P. Giacomin, C. Guy, Jaishree Bankoti, D. Finkelstein, K. Forbes, C. Workman, Scott A. Brown and 6 more. Nature Immunology, 2010
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Regulatory T cells (Treg cells) have a critical role in the maintenance of immunological self-tolerance. Here we show that treatment of naive human or mouse T cells with IL-35 induced a regulatory population, which we call 'iTR35 cells', that mediated suppression via IL-35 but not via the inhibitory cytokines IL-10 or transforming growth factor-β (TGF-β). We found that iTR35 cells did not express or require the transcription factor Foxp3, and were strongly suppressive and stable in vivo. Treg cells induced the generation of iTR35 cells in an IL-35- and IL-10-dependent manner in vitro and induced their generation in vivo under inflammatory conditions in intestines infected with Trichuris muris and within the tumor microenvironment (B16 melanoma and MC38 colorectal adenocarcinoma), where they contributed to the regulatory milieu. Thus, iTR35 cells constitute a key mediator of infectious tolerance and contribute to Treg cell–mediated tumor progression. Furthermore, iTR35 cells generated ex vivo might have therapeutic utility.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/1da3d6b77c905a549e01514bfefa9f02713ea003
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In Immunology
Citations in the corpus
- A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease (2019, background): “More recently, a new type of iTreg, called iTR35, has been identified which mainly produces the suppressive cytokine IL-35, not IL-10 or TGF-β [188, 189].”