Pro-Resolving lipid mediators and Mechanisms in the resolution of acute inflammation
By C. Buckley, D. Gilroy, C. Serhan. Immunity, 2014
776 citations recorded by the source corpus.
SUMMARY Inflammatory responses, like all biological cascades, are shaped by a delicate balance between positive and negative feedback loops. It is now clear that in addition to positive and negative checkpoints, the inflammatory cascade rather unexpectedly boasts an additional checkpoint, a family of chemicals that actively promote resolution and tissue repair without compromising host defence. Indeed the resolution phase of inflammation is just as actively orchestrated and carefully choreographed as its induction and inhibition. In this review we explore the immunological consequences of these omega-3-derived specialized pro-resolving mediators (SPMs) and discuss their place within what is currently understood of the role of the arachidonic acid-derived prostaglandins, lipoxins and their natural C15-epimers. We propose that treatment of inflammation should not be restricted to the use of inhibitors of the acute cascade (antagonism) but broadened to take account of the enormous therapeutic potential of inducers (agonists) of the resolution phase of inflammation.
Subfields: Biochemistry, Nutrition and Dietetics, Pharmacology
View Paper: https://www.semanticscholar.org/paper/af4db8b3e261d7725e92643bb0c2a3475a33f4fd
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Biochemistry
In Nutrition and Dietetics
Citations in the corpus
- Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs. (2015, background): “Combinations of sequential LOX activities (and sometimes including epoxygenase and hydrolase activities) results in the formation of di- and tri-hydroxy FAs, which includes the lipoxins, resolvins, protectins, and maresins (14, 16).”
- Pathophysiology of Myocardial Infarction (2015, neutral): “of necrotic cells (the main source of proinflammatory stimuli), but is an active process that involves activation of multiple inhibitory pathways (39, 110).”
- Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines (2018, background): “In normal inflammation SPMs do not compromise host immune competence with examples of pro-resolving mediators increasing survival from infections in mouse models (28, 29).”
- Skin Acute Wound Healing: A Comprehensive Review (2019, background): “Efferocytosis of apoptotic neutrophils by inflammatory macrophages stimulates the synthesis of miR-21, promoting the anti-inflammatory phenotype of the postefferocytotic macrophage [81, 82].”
- Phagocytosis: An Immunobiologic Process. (2016, background): “…as elastase, collagenase, and urokinase), proinflammatory (TNF, IL-1b, and IL-6) and anti-inflammatory (transforming growth factor beta and IL-10) cytokines and chemokines, and various lipid metabolites involved in phospho-inositol metabolism and resolution of inflammation (Buckley et al., 2014).”