Natural regulatory T cells in infectious disease

By Y. Belkaid, B. Rouse. Nature Immunology, 2005

1,158 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/f642205a9c75217114caa4bf1acdef6300160f80

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. E. Wherry
2. Shimon Sakaguchi
3. Gordon D. Brown
4. B. Guy
5. C. Serhan
6. Y. Belkaid

In Immunology

1. Shimon Sakaguchi
2. V. Kuchroo
3. Tomoyuki Yamaguchi
4. C. Serhan
5. E. Wherry
6. M. Oukka
7. T. Nomura
8. Y. Belkaid

Citations in the corpus

• Dectin-1: a signalling non-TLR pattern-recognition receptor (2006, background): “These cytokines contribute to the development of regulatory T cell”
• Pro-Resolving lipid mediators and Mechanisms in the resolution of acute inflammation (2014, background): “Classically studied in the setting of chronic infection, the potential for Treg cell numbers, activation and functional capacity to influence the outcome of pathogen-host interactions is well established (Belkaid and Rouse, 2005).”
• Regulatory T cells and immune tolerance. (2008, background): “Removal or reduction of CD25 + CD4 + Tregs also provokes effective tumor immunity in otherwise nonresponding animals and augments microbial immunity in chronic infection , leading to eradication of tumors or microbes, respectively (reviewed in Wang and Wang, 2007; Belkaid and Rouse, 2005).”
• Suppression of allergic airway inflammation by helminth-induced regulatory T cells (2005, neutral): “As with other instances of T reg cell responses to pathogens (66), these issues are currently under active investigation.”
• Redefining chronic viral infection. (2009, neutral): “(Tregs) (Belkaid and Rouse, 2005) in the equilibrium established during chronic viral infection.”
• Regulatory T cells and infection: a dangerous necessity (2007, background): “Targeting the molecules involved in regulatory T-cell activity in vivo , such as CTLA4, TGFβ or IL-10, alone or in combination, has proved effective in controlling many chronic infections (reviewed in Ref”
• T cell exhaustion (2011, background): “The mechanisms of suppression of immunity by T reg cells in vivo are incompletely understood, although pathways such as IL-10, TGF-β and inhibitory receptors have been linked to thi”
• Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation (2008, background): “The resistance of Treg-mediated CD80/86 down-regulation to DC-maturating microbial stimuli, such as LPS and Zymosan, could be important for Tregs to tune the intensity of antimicrobial immune responses (33).”
• Protective immune mechanisms in helminth infection (2007, background): “, suggesting a role for these T Reg cells in helminth-induced modulation of inflammatory disease”
• The perfect mix: recent progress in adjuvant research (2007, background): “It is important to have referees keeping each game under control and eventually signalling full time, and this role is filled by regulatory T (T Reg ) cells , which are capable of modulating both T H 1 and T H 2 response”
• Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression (2007, background): “T reg cells also suppress natural immune responses to parasites (4) and viruses (5) and inhibit or attenuate antitumor immunity induced by cancer vaccines.”