Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs.

By M. Bohnsack, K. Czaplinski, D. Gorlich. RNA: A publication of the RNA Society, 2004

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View Paper: https://www.semanticscholar.org/paper/3411089537081eec4a602bd6aa60d18918838222

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Citations in the corpus

MicroRNAs in development and disease. (2011, background): “Following completion of this nuclear processing step, the stem-loop pre-miRNA is exported out of the nucleus via exportin-5 in a RanGTP-dependent fashion (50, 394, 692) and into the cytoplasm, where it is further processed by Dicer to yield the functional singlestranded mature 20 –22 ribonucleotide ”
microRNA-directed phasing during trans-acting siRNA biogenesis in plants. (2005, background): “However, as shown using the hst-1 mutant (Bollman et al., 2003; Peragine et al., 2004), hst15 had several developmental abnormalities, including a more rapid juvenile-to-adult phase transition, leaf curling and epinasty, altered silique phyllotaxy, and small flowers (Figure 2A).”
SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis. (2004, background): “HST is the ortholog of the pre-miRNA nuclear export receptor exportin 5 (Bollman et al. 2003; Yi et al. 2003; Bohnsack et al. 2004; Lund et al. 2004), whereas SQN is the ortholog of cyclophilin 40 (Berardini et al. 2001).”
Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex. (2006, background): “Following this initial processing, the resulting pre-miRNAs are exported by the nuclear transport factor, exportin-5 (Exp5) (Bohnsack et al., 2004; Lund et al., 2004; Yi et al., 2003).”
microPrimer: the biogenesis and function of microRNA (2005, background): “The terminal methyl group is added by the S-adenosyl methionine (SAM)-dependent methyltranferase HEN1, and the modification of the miRNA by HEN1 either protects the miRNA from further modification or degradation, or may facilitate its assembly into the RISC (Boutet et al., 2003; Yu et al., 2005).”
MicroRNAs: New Biomarkers for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Breast Cancer (2015, background): “The generated pre-miRNAs are then exported from the nucleus to the cytoplasm by exportin 5 (XPO5) [27-29], where they are cleaved by the RNase III enzyme Dicer 1 in union with transactivation-responsive RNA-binding protein 2 (TARBP2) and AGO2 (DICER complex).”
Metazoan MicroRNAs (2018, background): “After export to the cytoplasm through the action of Exportin 5 and RAN–GTP (Yi et al., 2003; Bohnsack et al., 2004; Lund et al., 2004), the pre-miRNA is further processed by Dicer (Grishok et al.”
The role of PACT in the RNA silencing pathway (2006, background): “…while siRNAs are generated from long dsRNAs. siRNAs can be further classified into transacting siRNA (tasiRNA), repeat-associated siRNA (rasiRNA), and small scan RNA (scnRNA). miRNAs are transcribed from endogenous genes by RNA polymerase II (Cai et al, 2004; Lee et al, 2004a; Kim, 2005a).”
MicroRNA genes are transcribed by RNA polymerase II (2004, background): “The processing intermediate, pre-miRNA, is exported out of the nucleus by exportin-5 (Exp5), member of the Ran- dependent nuclear transport receptor family (Yi et al, 2003; Bohnsack et al, 2004; Lund et al, 2004).”
A combined computational and microarray-based approach identifies novel microRNAs encoded by human gamma-herpesviruses. (2006, background): “The pre-miRNA is then exported to the cytoplasm (Yi et al. 2003; Bohnsack et al. 2004; Lund et al. 2004; Zeng and Cullen 2004), where the hairpin structure is recognized by a complex containing the RNase Dicer, which processes the pre-miRNA into the mature effector z 22-nt miRNA molecule (Bernstein…”
MicroRNAs in cell proliferation, cell death, and tumorigenesis (2006, background): “Pre-miRNAs are rapidly exported to the cytoplasm by the nuclear export factor exportin 5 which uses Ran-GTP as a cofactor (Yi et al, 2003; Bohnsack et al, 2004; Lund et al, 2004).”
Perspective: machines for RNAi. (2005, background): “The pre- miRNA liberated by Drosha is exported from the nucleus by the protein Exportin 5 (Yi et al. 2003; Bohnsack et al. 2004; Lund et al. 2004; Zeng and Cullen 2004), then cut by Dicer in the cytoplasm to produce the mature miRNA (Grishok et al. 2001; Hutvágner et al. 2001; Ketting et al. 2001;…”
Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. (2004, background): “Pre-miRNAs, which form short RNA hairpins bearing a 2-nt 3 overhang, are then bound by the nuclear export factor Exportin 5, which transports them to the cytoplasm (Yi et al. 2003; Bohnsack et al. 2004; Lund et al. 2004).”
Small RNA sorting: matchmaking for Argonautes (2010, background): “The nuclear export protein Exportin 5 recognizes the 2-nt single-stranded 3′ overhang of the pre-miRNA (characteristic of RNase III-mediated cleavage) and actively transports it in a Ran–GTP-dependent manner to the cytoplas”