Small RNA sorting: matchmaking for Argonautes

By Benjamin Czech, Gregory J. Hannon. Nature reviews genetics, 2010

717 citations recorded by the source corpus.

Small RNAs directly or indirectly impact nearly every biological process in eukaryotic cells. To perform their myriad roles, not only must precise small RNA species be generated, but they must also be loaded into specific effector complexes called RNA-induced silencing complexes (RISCs). Argonaute proteins form the core of RISCs and different members of this large family have specific expression patterns, protein binding partners and biochemical capabilities. In this Review, we explore the mechanisms that pair specific small RNA strands with their partner proteins, with an eye towards the substantial progress that has been recently made in understanding the sorting of the major small RNA classes — microRNAs (miRNAs) and small interfering RNAs (siRNAs) — in plants and animals.

Subfields: Plant Science

View Paper: https://www.semanticscholar.org/paper/165dfc925ba0e2922b54d3e4ffd741055acba02a

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In Plant Science

1. Eric C. Lai
2. Jeannie T. Lee

Citations in the corpus

• MicroRNAs: New Biomarkers for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Breast Cancer (2015, background): “Like protein-coding genes, miRNAs with their own promoters are almost exclusively transcribed by RNA polymerase II in a primary transcript called pri-miRNA [24] (Figure 1).”
• microRNAs in action: biogenesis, function and regulation (2023, background): “Following discard of the miRNA* species (also known as the passenger strand), a process governed by sequence and structural features of the duplex, the mature single-stranded miRNA guides the Ago complex to repress complementary RNA targets 11 .”
• Current prospects for RNA interference-based therapies (2011, background): “The two main types of small RNAs involved in gene silencing are microRNAs (miRNAs) and siRNAs, and their processing and targeting is summarized in FIG. 1 (further details can be found in recent reviews [10] [11] [12] .”
• Long Noncoding RNAs: Past, Present, and Future (2013, background): “We refer readers to the many excellent recent reviews on these topics (Peculis 2000; Xiao et al. 2002; Henras et al. 2004; Okamura and Lai 2008; Kim et al. 2009; Feuerhahn et al. 2010; Blackburn and Collins 2011; Czech and Hannon 2011; Siomi et al. 2011).”