Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs.

By Xuezhong Cai, C. Hagedorn, Bryan R. Cullen. RNA: A publication of the RNA Society, 2004

2,002 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9d4112ea3f6a7118dfa06b0d7ef19d633cec473a

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Citations in the corpus

Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. (2006, background): “Recent studies have also shown that some miRNAs are downregulated in various human cancers, indicating that they may act as tumor suppressors (Calin et al., 2002; Michael et al., 2003; Takamizawa et al., 2004).”
MicroRNAs: new regulators of immune cell development and function (2008, background): “First, miRNA is transcribed mainly by RNA polymerase II, which produces a primary transcript containing the mature miRNA sequence and a varying amount of flanking regio”
microRNAs in cancer (2013, background): “In addition, miRNA profiles can subgroup acute lymphoblastic leukemia (ALL) specimens into three major groups: one containing all t(9;22) BCR/ABL-positive and t(12;21) TEL/AML1-positive samples, a second containing T cell ALL samples, and a third containing the MLL gene rearrangement (35).”
MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene (2008, result): “This result was further supported by a reporter experiment in which the expression of a luciferase gene driven by the promoter for the miR-21 gene (Cai et al., 2004) did not respond to TPA treatment (data not shown).”
MicroRNAs: the fine-tuners of Toll-like receptor signalling (2011, background): “Because miRNAs are also transcribed by RNA polymerase I”
Long noncoding RNAs: functional surprises from the RNA world. (2009, background): “Despite containing an almost perfectly double-stranded helix of ;300 base pairs, this transcript is not a Dicer substrate because branched structures flanking the central double-stranded helix inhibit its processing.”
Normal microRNA Maturation and Germ-Line Stem Cell Maintenance Requires Loquacious, a Double-Stranded RNA-Binding Domain Protein (2005, background): “II [4–8] and processed in the nucleus by the multidomain”
Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients (2008, background): “First, miRNAs are transcribed by RNA polymerase II into a long primary miRNA (pri-miRNA) transcript [7,8].”
Processing of intronic microRNAs (2007, background): “However, more careful analysis revealed that a significant number of miRNAs are in the introns of TUs that are predicted or annotated to be protein-coding.”
Exporting RNA from the nucleus to the cytoplasm (2007, background): “The genes that encode miRNAs can be transcribed by either Pol II or Pol II”
microRNAs as oncogenes and tumor suppressors. (2007, background): “Detailed deletion analysis indicated that these two miRNAs are the only two genes within the small (30 kb) common region which are lost in CLL patients, and expression analysis indicated that miR-15a and miR-16a were either absent or down-regulated in the majority (∼ 68”
MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “(2004) indicates that the majority of miRNA are transcribed by RNA polymerase II (pol II) [38, 42-44].”