MicroRNAs in cell proliferation, cell death, and tumorigenesis
By Hun-Way Hwang, Joshua T. Mendell. British Journal of Cancer, 2006
1,286 citations recorded by the source corpus.
MicroRNAs (miRNAs) are a recently discovered class of ∼18–24 nucleotide RNA molecules that negatively regulate target mRNAs. All studied multicellular eukaryotes utilise miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. It is now apparent that abnormal miRNA expression is a common feature of human malignancies. In this review, we will discuss how miRNAs influence tumorigenesis by acting as oncogenes and tumour suppressors.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/7508f24fe21edde4129922fde0de4536e2583ee9
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In Cancer Research
In Molecular Biology
Citations in the corpus
- MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “MiRNAs play a vital role in regulating numerous metabolic and cellular pathways, notably those controlling cell proliferation, differentiation and survival [13-18, 238-240].”
- Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer. (2007, neutral): “They have been shown to play a fundamental role in diverse physiological and pathological processes including proliferation, apoptosis, differentiation, and cell fate determination.(6,7) Recent evidence indicates that miRNAs can function as tumor suppressors and oncogenes.”