Metazoan MicroRNAs

By David P. Bartel. Cell, 2018

3,207 citations recorded by the source corpus.

MicroRNAs (miRNAs) are ~22-nt RNAs that direct posttranscriptional repression of mRNA targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs help sculpt the expression of most mRNAs. This article reviews advances in our understanding of the defining features of metazoan miRNAs and their biogenesis, genomics, and evolution. It then reviews how metazoan miRNAs are regulated, how they recognize and cause repression of their targets, and the biological functions of this repression, with a compilation of knockout phenotypes that shows that important biological functions have been identified for most of the broadly conserved miRNAs of mammals.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/37476120cc336d1bad2f3a2e189dc38b7546d616

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Citations in the corpus

Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease (2019, methodology): “miRNAs are regulatory small non-coding RNAs of approximately 22-nt produced by virtually all cells in the body (Bartel, 2018; Ludwig et al., 2016).”
Non-coding RNAs in disease: from mechanisms to therapeutics (2023, neutral): “The complexity of such regulation is demonstrated by the fact that a single miRNA can target hundreds of different mRNAs and that multiple miRNAs can target the same mRNA 29 .”
An overview of microRNAs: Biology, functions, therapeutics, and analysis methods (2018, background): “NOT and its recruitment of DEAD‐box helicase 6 ( DDX6), that binds the decapping complex and is reported to inhibit translation (Bartel, 2018).”
Noncoding RNA:RNA Regulatory Networks in Cancer (2018, background): “These seminal findings were accompanied by various studies that have provided important insights into the molecular mechanisms that dictate effective ceRNA crosstalk, a topic of much debate [12,36].”
The Role of Non-coding RNAs in Oncology (2019, background): “One strand of the miRNA duplex, the guide strand, is loaded onto an Argonaute protein and selected to form the RNA-induced silencing complex (RISC) containing the mature 22 nucleotide miRNA (see recent reviews by (Anastasiadou et al., 2018a; Bartel, 2018)).”