microPrimer: the biogenesis and function of microRNA

By T. Du, Phillip D. Zamore. Development, 2005

848 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/bfd1720169cea126e0ee13e48aa11d486426c490

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In Plant Science

Citations in the corpus

Functions of microRNAs and related small RNAs in plants (2006, background): “miRNAs derive from long, single-stranded RNAs (ssRNAs) that have the ability to fold and form imperfectly double-stranded RNAs (dsRNAs), which are processed sequentially by RNase III proteins of the Drosha/Dicer famil”
MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype (2007, background): “Pre-miRNAs are exported from the nucleus by Exportin-5 [24], processed by the RNase III enzyme Dicer, and incorporated into an Argonaute-containing RNA-induced silencing complex (RISC) [25].”
MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “Human miRNA biogenesis is a two-step process, with both nuclear and subsequent cytoplasmic cleavage events performed by two ribonuclease III endonucleases, Drosha and Dicer [75-81].”
Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes. (2006, background): “Key factors required for the biogenesis and function of these small RNAs are Dicer and Argonaute proteins (for review, see Tomari and Zamore 2005).”
Post-transcriptional small RNA pathways in plants: mechanisms and regulations. (2006, background): “…fold-back stem-loops that are first cleaved by the RNase III Drosha on each arm of the stemloop to liberate the pre-miRNA (Ambros 2004; Bartel 2004; Du and Zamore 2005; Kim 2005), which is subsequently exported to the cytoplasm by Exp5 and cleaved by the RNase III Dicer to liberate the loop and…”
Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. (2007, background): “There is increasing recognition that contextual features may also govern this interaction (Ambros, 2004; Du and Zamore, 2005; Vella et al., 2004).”
Mammalian mirtron genes. (2007, background): “Following its export to the cytoplasm, Dicer cleaves on the loop side of the hairpin to generate an miRNA:miRNA* duplex, one strand of which is preferentially incorporated into a silencing complex (Du and Zamore, 2005).”
The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis (2008, background): “Mature miRNAs are single-stranded RNAs consisting of 21–24 nucleotides that are generated from sequential processing of primary miRNA transcripts by Drosha and Dice”
Non-coding RNA. (2006, background): “It is estimated that approximately one-third of human proteincoding genes are controlled by miRNAs [reviewed in (119)].”
miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. (2006, background): “MicroRNAs (miRNAs) are a class of endogenously expressed small regulatory noncoding RNAs that are thought to negatively regulate target mRNAs by binding with imperfect complementarity in their 3 0 UTR (Ambros, 2004; Bartel, 2004; Du and Zamore, 2005; He and Hannon, 2004).”
A combined computational and microarray-based approach identifies novel microRNAs encoded by human gamma-herpesviruses. (2006, background): “MicroRNAs (miRNAs) are small, noncoding, z 22-nt RNAs that bind directly to mRNA targets and inhibit their ability to express protein products (for review, see Du and Zamore 2005; Hammond 2005; Kim 2005).”
A guide through present computational approaches for the identification of mammalian microRNA targets (2006, methodology): “For a detailed description of the biogenesis and targeting mechanisms of miRNAs we direct the reader to several of the many comprehensive reviews on the topi”
Biological functions of microRNAs: a review (2011, background): “The Microprocessor cleaves the pri-miRNA to generate a shorter hairpin of about 70 nt length—the pre-miRNA [ 11 ].”
Specific association of Piwi with rasiRNAs derived from retrotransposon and heterochromatic regions in the Drosophila genome. (2006, background): “It is suggested that a complex for loading rasiRNAs specifically onto Piwi exists; as the Dicer1/ Loquacious (R3D1) and Dicer2/R2D2 complexes load, after processing, mature miRNA and guide siRNA onto AGO1 and AGO2, respectively.”