The role of PACT in the RNA silencing pathway

By Yoontae Lee, Inha Hur, Seong-Yeon Park, Young‐Kook Kim, M. Suh, V. Narry Kim. EMBO Journal, 2006

765 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/de07122c3f8a09411ee73da4badfd7b94a3deedf

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In Molecular Biology

Citations in the corpus

Strategies for silencing human disease using RNA interference (2007, background): “and protein activator of protein kinase PKR (PACT”
microRNAs in cancer (2013, background): “Human Dicer interacts with two related proteins, TRBP (transactivation response RNA-binding protein) (21) and PACT (protein activator of the interferon, also known as PRKRA) (22).”
Small silencing RNAs: an expanding universe (2009, neutral): “In the cytoplasm, Dicer and its dsRBD partner protein, TRBP in mammals and LOQS in flies, cleaves the pre-miRN”
MicroRNA: Biogenesis, Function and Role in Cancer (2010, methodology): “There is evidence that Dicer, TRBP, PACT and Ago2 can all interact but no group has yet to describe a processing complex composed of all proteins.”
Posttranscriptional regulation of microRNA biogenesis in animals. (2010, background): “In the cytoplasm, the pre-miRNA gets further ‘‘diced’’ into a 22 nt long miRNA duplex by Dicer, another RNase III enzyme, in collaboration with the dsRBD Molecular Cell 38, May 14, 2010 ª2010 Elsevier Inc. 323 proteins TRBP/PACT (Chendrimada et al., 2005; Haase et al., 2005; Lee et al., 2006).”
MicroRNA regulation by RNA-binding proteins and its implications for cancer (2011, background): “Another cofactor, the protein activator PACT (also known as PRKRA), has a similar function to TARBP2 in that it recognizes the same binding domain of Dice”
The long and short of microRNA. (2013, background): “Biochemical mapping of the interaction between Dicer and TRBP or PACT revealed that both proteins associate via their C-terminal dsRBD with the helicase domains of Dicer (Lee et al., 2006) and close to its catalytic core, suggesting that they may affect its activity.”
Molecular mechanisms of RNA interference (2013, neutral): “The human system includes a solitary Dicer and two dsRBPs, TRBP and PACT, that play poorly delineated roles in small RNA processing (50).”
Antiviral immunity directed by small RNAs. (2007, neutral): “On the other hand, human Dicer processes dsRNA into siRNAs in vitro and in some human cultured cells (Hammond, 2005), and both PACT and TRBP play important roles in mammalian RNA silencing (Lee et al., 2006).”