P. Ratcliffe

Cancer Research · 2000–2011

A researcher in the Science corpus: 18 papers; trusts 9 researchers and is trusted by 26 researchers here, as inferred from the citation graph.

Subfields

• Cancer Research — 140 citations into it; #84 of 1,780 by trust here, #60 by citations
• Molecular Biology — 139 citations into it; #3,820 of 17,773 by trust here, #1,030 by citations
• Genetics — 36 citations into it; #1,259 of 6,854 by trust here, #887 by citations
• Physiology — 31 citations into it; #351 of 2,276 by trust here, #127 by citations

Whom P. Ratcliffe trusts overall

Their strongest outbound trust, strongest first, inferred from their citations.

1. G. Semenza
2. W. Kaelin
3. Cheng-Jun Hu
4. Roland H. Wenger

Who trusts P. Ratcliffe overall

1. G. Semenza
2. Sophia Y. Lunt
3. W. Kaelin
4. Jung-whan Kim
5. Navdeep S. Chandel
6. M. V. Vander Heiden
7. V. Haase
8. Aude Carreau
9. P. Kapahi
10. Eyal Gottlieb

Papers from P. Ratcliffe's perspective

Ordered by how strongly the researchers P. Ratcliffe trusts endorse each paper. Same corpus, a different order for every researcher.

1. Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation (Molecular and Cellular Biology)
2. Targeting HIF-1 for cancer therapy (Nature Reviews. Cancer)
3. Regulation of angiogenesis by hypoxia: role of the HIF system (Nature Medicine)
4. Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. (Cell Metabolism)
5. Hypoxia — a key regulatory factor in tumour growth (Nature Reviews. Cancer)
6. Transcription Factor HIF-1 Is a Necessary Mediator of the Pasteur Effect in Mammalian Cells (Molecular and Cellular Biology)
7. Differentiating the functional role of hypoxia‐inducible factor (HIF)‐1α and HIF‐2α (EPAS‐1) by the use of RNA interference: erythropoietin is a HIF‐2α target gene in Hep3B and Kelly cells
8. Oxygen sensing by HIF hydroxylases (Nature reviews. Molecular cell biology)
9. Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1α (Science)
10. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression (Nature)

Their papers

• Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation (2001) — 4,904 citations
• Regulation of angiogenesis by hypoxia: role of the HIF system (2003) — 2,531 citations
• C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. (2001) — 3,389 citations
• Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein* (2000) — 822 citations
• Independent function of two destruction domains in hypoxia‐inducible factor‐α chains activated by prolyl hydroxylation (2001) — 1,106 citations
• Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization (2009) — 833 citations
• The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases (2011) — 1,001 citations
• Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor* (2004) — 1,117 citations
• Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family* (2002) — 716 citations
• High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq. (2011) — 724 citations
• Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. (2008) — 3,162 citations
• HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. (2005) — 965 citations
• Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma (2005) — 993 citations
• Oxygen sensing by HIF hydroxylases (2004) — 2,112 citations
• Genetic Analysis of the Role of the Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-inducible Factor (HIF) in Regulating HIF Transcriptional Target Genes* (2004) — 147 citations
• HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. (2001) — 733 citations
• Hypoxia-inducible expression of tumor-associated carbonic anhydrases. (2000) — 1,347 citations
• The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages (2000) — 1,144 citations