Hypoxia — a key regulatory factor in tumour growth

By Adrian L. Harris. Nature Reviews. Cancer, 2002

5,276 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/087cef763968a688c808f840e2f99e2b625ba7de

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Citations in the corpus

HIF-1 as a target for drug development (2003, background): “Most importantly, overexpression of HIF-1α or HIF-2α have been implicated as poor prognostic indicators for a variety of tumour”
Tumor cell metabolism: cancer's Achilles' heel. (2008, background): “…M2; SCO2, synthesis of cytochrome c oxidase 2; SDH, succinate dehydrogenase; TSC, tuberous sclerosis complex; VDAC, voltage-dependent anion channel; VHL, von HippelLindau ubiquitin ligase. inflammatory, metabolic, and oxidative stress (Harris, 2002; Semenza, 2007; Taylor and Pouyssegur, 2007).”
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. (2003, background): “Vascular endothelial growth factor (VEGF) is a major adaptation and survival under hypoxia (Brahimi-Horn et al., 2001; Harris, 2002; Maxwell and Ratcliffe, 2002; Semenza, mediator of angiogenesis (Carmeliet et al., 1996; Risau, 1997); whose expression is induced under hypoxic conditions (Gold-…”
A tense situation: forcing tumour progression (2009, background): “Tumour-associated compression stress can induce tumour angiogenesis by directly increasing expression of vascular endothelial growth factor A ( VEGFA ) or by indirectly blocking the existing vasculature surrounding the tumour mass to promote hypoxia and VEGFA secretio”
Hypoxia-Inducible Factor-1 (HIF-1) (2006, neutral): “Immunohistochemical analyses demonstrated that there are detectable levels of HIF-1 protein in benign tumors, elevated levels in primary malignant tumors, and a marked amount in tumor metastases, in contrast to its absence in normal tissues (Zhong et al., 1999; Harris, 2002).”
Dissecting the metastatic cascade (2004, background): “, whereas HIF-1α has previously been associated with metastasi”
Reactive oxygen species in cancer (2010, background): “The adaption of tumor cells to hypoxia contributes to the malignant phenotype and to aggressive tumor progression [200].”
Exploiting tumour hypoxia in cancer treatment (2004, background): “, increases expression of genes associated with angiogenesi”
A MicroRNA Signature of Hypoxia (2006, background): “Tumors with widespread low oxygenation tend to exhibit increased invasion and resistance to conventional therapy (9).”
Role of hypoxia in cancer therapy by regulating the tumor microenvironment (2019, background): “Moreover, HIF can reversely convert carbon dioxide and water produced by the activation of carbonic anhydrase IX or XII into HCO3 , which diffuses out of the cell membrane, resulting in excess HCO3 − in the TME and a decrease in pH [9].”