Hypoxia-inducible expression of tumor-associated carbonic anhydrases.

By C. Wykoff, N. Beasley, P. Watson, K. Turner, J. Pastorek, A. Sibtain, G. Wilson, H. Turley, K. Talks, P. Maxwell and 3 more. Cancer Research, 2000

1,347 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/0207d156cb1e47a995f066951d911442b3722b47

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Citations in the corpus

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer (2009, background): “The ca12 gene is also induced in hypoxia [23, 145], via a HIF-1dependent mechanism [24].”
Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. (2011, background): “In addition, other studies have shown a clear correlation between the expression of CAIX, hypoxia-induced HIF-1α and altered metabolic proteins such as GLUT-1 (4, 9, 38), althoughHIF-1α is a more labile protein, and thus more susceptible to pre-analytical variables.”
Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. (2009, background): “hypoxia in tumor cells, but its dependence on HIF is not well established (22).”
Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy. (2003, background): “However, recent studies now indicate that expression of CAIX is regulated by the hypoxia-inducible factor 1 transcriptional complex that mediates expression of a number of genes in response to hypoxic conditions (35).”
Interfering with pH regulation in tumours as a therapeutic strategy (2011, background): “They eliminate acidic catabolites by ion transporters and pumps to preserve a slightly alkaline intracellular pH (pH i ), which is optimal for cell proliferation and tumour surviva”
Hypoxia-Inducible Factor-1 (HIF-1) (2006, unknown): “…Takahashi et al., 2000 Glucose metabolism Adenylate kinase-3 O’Rourke et al., 1996 Aldolase-A,C (ALDA,C) Semenza et al., 1996 Carbonic anhydrase-9 Wykoff et al., 2000 Enolase-1 (ENO1) Semenza et al., 1996 Glucose transporter-1,3 (GLU1,3) Chen et al., 2001 Glyceraldehyde phosphate dehydrogenase…”
Differentiating the functional role of hypoxia‐inducible factor (HIF)‐1α and HIF‐2α (EPAS‐1) by the use of RNA interference: erythropoietin is a HIF‐2α target gene in Hep3B and Kelly cells (2004, background): “It is highly expressed in a large number of human tumors and known to be associated with tumor hypoxia and to be inducible by HIF (35).”