Differentiating the functional role of hypoxia‐inducible factor (HIF)‐1α and HIF‐2α (EPAS‐1) by the use of RNA interference: erythropoietin is a HIF‐2α target gene in Hep3B and Kelly cells

By C. Warnecke, Z. Zaborowska, J. Kurreck, V. Erdmann, U. Frei, M. Wiesener, Kai-Uwe Eckardt. 2004

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The N-Terminal Transactivation Domain Confers Target Gene Specificity of Hypoxia-inducible Factors HIF-1α and HIF-2α (2007, background): “Hep3B cells were selected to address this question, because Hep3B cells have been shown to express both HIF-1 and HIF-2 proteins, and they exhibit high levels of hypoxic induction of HIF targets such as the glycolytic genes PGK and LDHA (Hu et al., 2003; Warnecke et al., 2004 ).”
Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma (2005, result): “Such a scenario begs the following question: is upregulation of HIF-2 or downregulation of HIF-1 the primary event in driving the observed bias? Currently, we cannot answer this question, though it is of interest that a recent report has described a shortened HIF-1 transcript in 786-O cells ( 44 ) a”
ADAPTIVE AND MALADAPTIVE CARDIORESPIRATORY RESPONSES TO CONTINUOUS AND INTERMITTENT HYPOXIA MEDIATED BY HYPOXIA-INDUCIBLE FACTORS 1 AND 2 (2012, background): “HIF-2 appears to play a key role in regulating erythropoiesis in adult mice (104, 293, 347), although HIF-1 is also required for yolk sac erythropoiesis (368), renal EPO production in response to acute hypoxic episodes (34), and the development of polycythemia in response to chronic hypoxia (370).”