Regulation of angiogenesis by hypoxia: role of the HIF system
By C. Pugh, P. Ratcliffe. Nature Medicine, 2003
2,531 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/aa3aa5b849387179c5fad2be568822cbde88679f
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Citations in the corpus
- Macrophage-Induced Blood Vessels Guide Schwann Cell-Mediated Regeneration of Peripheral Nerves (2015, background): “pro-angiogenic factors such as VEGF (Krock et al., 2011; Pugh and Ratcliffe, 2003).”
- Cloning of hif-1α and hif-2α and mRNA expression pattern during development in zebrafish (2007, background): “In eukaryotic organisms, oxygen homeostasis is critical for normal development and physiology and therefore, hypoxia has been proposed as a key regulator of various morphogenetic processes such as angiogenesis ( Pugh and RatcliVe, 2003 ), lung, brain and cartilage development (Compernolle et al., 20”
- Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. (2005, methodology): “) and ascorbate as cofactors (Kaelin, 2002; Scho-field and Zhang, 1999).”
- Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer (2004, background): “Recently, a family of prolyl hydroxylases related to the Egl-9 gene product from Caenorhabditis elegans were identified as HIF prolyl hydroxylase”
- VEGF receptor signalling ? in control of vascular function (2006, background): “Hypoxia allows the stabilization of hypoxia-inducible factors (HIFs) that bind to specific promoter elements that are present in the promoter region of VEGF”
- The role of the unfolded protein response in tumour development: friend or foe? (2004, neutral): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5328">uPA”
- Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development (2013, background): “De Bock K, Mazzone M, Carmeliet P (2011) Antiangiogenic therapy, hypoxia, and metastasis: Risky liaisons, or not? Nat Rev Clin Oncol 8(7):393–404.”
- Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila (2015, neutral): “In many different physiological contexts, tissues containing stem cells are exposed to low levels of dietary nutrients or oxygen (Barker, 1995; Dunwoodie, 2009; Pugh and Ratcliffe, 2003).”
- Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1 (2007, background): “Earlier studies using transgenic animal models have reported that c-Myc-deficient mice display serious defects in the development of blood vessels, angiogenesis, and erythropoiesis, suggesting that c-Myc participates in regulating VEGF expression and angiogenesis (67, 77).”
- Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes. (2010, background): “Indeed, one of the key responses to hypoxia is the induction of an angiogenic program (26).”
- Targeting the tumour vasculature: insights from physiological angiogenesis (2010, background): “Mutations in the tumour suppressor gene von Hippel Lindau ( VHL ) notoriously enhance the activity of HIF1α, especially in renal cell carcinoma, by preventing its polyubiquitylation and proteasomal degradatio”
- Protein S-nitrosylation: purview and parameters (2005, background): “The coordinated transcriptional control of several genes through binding to hypoxia-responsive elements (HREs) by the α,β-heterodimeric proteins hypoxia-inducible factor (HIF)1 and 2 has an important role in regulating cellular O 2 homeostasi”