The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages

By K. Talks, H. Turley, K. Gatter, P. Maxwell, C. Pugh, P. Ratcliffe, Adrian L. Harris. 2000

1,144 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Physiology

View Paper: https://www.semanticscholar.org/paper/e7147d8c273fb6e06f40b3db04d833f8006f7f39

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. G. Semenza
2. P. Vaupel
3. A. Mayer
4. P. Schumacker
5. Amato J. Giaccia
6. R. Guzy
7. Richard J. Johnson
8. V. Nizet

In Genetics

1. G. Semenza
2. R. Guzy
3. P. Schumacker
4. Amato J. Giaccia
5. Richard J. Johnson
6. V. Nizet
7. P. Vaupel
8. S. Colgan

In Physiology

1. P. Vaupel
2. P. Schumacker
3. R. Guzy
4. Roland H. Wenger
5. Richard J. Johnson
6. Amato J. Giaccia
7. G. Semenza
8. A. Sica

Citations in the corpus

• Targeting HIF-1 for cancer therapy (2003, background): “4 ) revealed that HIF-1α is overexpressed in many human cancer”
• Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth (2008, neutral): “The combination of increased synthesis and decreased degradation leads to increased HIF-1 protein levels in many cancers (16, 17).”
• Cellular adaptation to hypoxia: O2‐sensing protein hydroxylases, hypoxia‐inducible transcription factors, and O2‐regulated gene expression (2002, background): “The three HIF subunits show partially overlapping expression patterns in vitro and in vivo (20, 24, 25).”
• HIF Transcription Factors, Inflammation, and Immunity (2014, background): “For example, HIF-2a is expressed in tumor-associated macrophages (Imtiyaz et al., 2010; Talks et al., 2000) as well as CD8 + T cells in response to hypoxia (Doedens et al., 2013), where its expression is influenced by cytokine exposure.”
• 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. (2003, background): “This occurs through HIF-1␣ protein hydroxylation on manolaki et al., 2001; Koukourakis et al., 2002; Schindl et al., 2002; Talks et al., 2000; Zhong et al., 1999).”
• Hypoxia-Inducible Factor-1 (HIF-1) (2006, neutral): “Overexpression of HIF-1 and HIF-2 was found in various human cancers, probably as a consequence of intratumoral hypoxia or genetic alteration (Zhong et al., 1999; Talks et al., 2000).”
• Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. (2002, background): “Moreover, it was recently shown that the majority of solid tumors, particularly those with a propensity for P-gp expression, stain positive for nuclear HIF-1 ( 55 ).”
• The role of myeloid cells in the promotion of tumour angiogenesis (2008, background): “Hypoxic macrophages are known to respond to hypoxia by upregulating hypoxia-inducible transcription factors (mainly hypoxia-inducible factors HIF1 and HIF2”
• HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations. (2013, neutral): “HIF-1 α homologs have been identified in all metazoan species analyzed and are expressed in all cell types, whereas HIF-2 α homologs are only found in vertebrates and are expressed in a restricted number of cell types (7, 8), although many cancer cells express both HIF-1 α and HIF-2 α (9, 10).”