Targeting HIF-1 for cancer therapy

By G. Semenza. Nature Reviews. Cancer, 2003

6,717 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5640c9cde91e6268f180d5c69c6f72785438ac29

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. G. Semenza
2. C. V. Dang
3. Navdeep S. Chandel
4. Rakesh K. Jain
5. M. V. Vander Heiden
6. Ralph J. Deberardinis
7. M. C. Simon
8. D. Hanahan

In Molecular Biology

1. G. Semenza
2. C. V. Dang
3. Rakesh K. Jain
4. Guido Kroemer
5. D. Hanahan
6. Navdeep S. Chandel
7. Ralph J. Deberardinis
8. Craig B. Thompson

Citations in the corpus

• Oxidation in rheumatoid arthritis (2004, background): “It should be noted that many cancer cells overexpress HIF-1α on a genetic basis, a phenomenon that presumably enhances their survival in hypoxic environments [ 131 ].”
• Hypoxia and hypoxia-inducible factors (HIFs): master regulators of metastasis (2010, background): “In neuroblastoma, hypoxia induces the expression of Delta-like 1 homolog (DLK1), which was shown to be essential for maintaining stemness and tumorigenicity (47).”
• Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. (2007, background): “Each of these cytokines can be produced by tumor cells, macrophages, and other stromal cells and are hypoxia-inducible (Casanovas et al., 2005; Semenza, 2003). sFlk1 induced a similar angiogenic rescue program (data not shown).”
• Hypoxia signalling in cancer and approaches to enforce tumour regression (2006, background): “HIF can induce a vast array of gene products controlling energy metabolism, neovascularization, survival, pH i and cell migration, and has become recognized as a strong promoter of tumour growt”
• AKT/PKB signaling: navigating downstream. (2007, neutral): “Akt signaling also leads to an increased production of the hypoxiainducible factor α (HIF1α and HIF2α) transcription factors, at least in part, through mTORC1-dependent translation (reviewed in Gordan and Simon, 2007; Semenza, 2003).”
• Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. (2005, background): “The expression of chemoattractant genes (MCP-1, colony- stimulating factor [CSF]-3, and plasminogen activator urokinase receptor [PLAUR]) was found in the SVF and increased in obesity.”
• Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer. (2016, background): “By recruiting transcriptional co-activators, HIFs regulate the expression of numerous genes involved in different processes including angiogenesis, metabolism, erythropoiesis, apoptosis, pH regulation, metastasis, and cellular differentiation (Semenza, 2003; Keith et al., 2012).”
• Dual role of hydrogen peroxide in cancer: possible relevance to cancer chemoprevention and therapy. (2007, background): “It is not surprising, therefore, that HIF-1 overexpression is observed in many human cancers and has been associated with increased patient mortality [40,41,44].”
• Hypoxia, HIF1 and glucose metabolism in the solid tumour (2008, background): “HIF1 inhibitors with metabolic effects Investigators are also attempting to inhibit the HIF1 transcription factor in an effort to block the metabolic effects as well as other physiological pathways that are regulated by HIF1 in the solid tumour (such as angiogenesis”