Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation

By Cheng-Jun Hu, Liyi Wang, Lewis A. Chodosh, B. Keith, M. C. Simon. Molecular and Cellular Biology, 2003

1,208 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/daa75f90bf1ecf7eff9888e990367e728b7f8d7d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. G. Semenza
2. C. V. Dang
3. M. C. Simon
4. W. Kaelin
5. Craig B. Thompson
6. Jung-whan Kim
7. P. Ratcliffe
8. Ping Gao

In Molecular Biology

1. G. Semenza
2. C. V. Dang
3. M. C. Simon
4. W. Kaelin
5. Ping Gao
6. P. Ratcliffe
7. Craig B. Thompson
8. Jung-whan Kim

In Physiology

1. G. Semenza
2. M. C. Simon
3. W. Kaelin
4. C. V. Dang
5. Jung-whan Kim
6. Richard J. Johnson
7. P. Ratcliffe
8. P. Schumacker

Citations in the corpus

• SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization (2011, background): “SIRT3 Opposes the Warburg Effect by Destabilizing HIF1a HIF1, the heterodimer of HIF1a andHIF1b, is the primary driver of increased glycolysis and lactate production during hypoxia (Gordan and Simon, 2007; Hu et al., 2003; Seagroves et al., 2001).”
• The N-Terminal Transactivation Domain Confers Target Gene Specificity of Hypoxia-inducible Factors HIF-1α and HIF-2α (2007, methodology): “WT HRE-Luciferase reporter, as well as mutant HRE-Luciferase reporter, were described by Hu et al. (2003).”
• Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. (2008, background): “Studies of transcriptional selectivity have defined exclusive HIF1a targets, exclusive HIF2a targets, and genes that are responsive to both HIF1a and HIF2a (Holmquist-Mengelbier et al., 2006; Hu et al., 2003; Raval et al., 2005).”
• Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1 (2007, background): “Although recent studies reported that adaptive responses to hypoxia such as induction of glycolytic enzyme genes are predominantly mediated by HIF-1 (25, 31 ), additional studies are necessary to address the effects of HIF-2 on transcriptional and oncogenic activities of c-Myc.”
• Transcriptional Regulation by Hypoxia Inducible Factors (2013, background): “Several studies demonstrate that HIF2A plays no role in glycolytic gene regulation, but rather induces the expression of genes involved in pluripotent stem cell maintenance and angiogenesis (Hu et al., 2003; Koh et al., 2011; Takeda et al., 2004).”
• HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. (2007, background): “…have shared targets, such as vascular endothelial growth factor (VEGF ) and adipose differentiation-related protein (ADRP), they also regulate unique gene targets, with HIF-1α regulating glycolytic enzymes (Hu et al., 2003), and HIF-2α activating the stem cell factor oct4 (Covello et al., 2006).”
• Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer. (2016, background): “Early studies showed that HIF-1 (but not HIF-2) induced expression of several glycolytic genes in various cell types,while unique HIF-2 target genes seemed to be cell type specific (Hu et al., 2003; Raval et al., 2005).”
• The role of oxygen availability in embryonic development and stem cell function (2008, background): “We have shown that HIF-2a, but not HIF-1a, binds to the Oct4 promoter and induces Oct4 expression in hypoxic cells if the Oct4 locus is in an 'open' configuration and not embedded in heterochromati”