HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors.

By H. Sowter, P. Ratcliffe, P. Watson, A. Greenberg, A. Harris. Cancer Research, 2001

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The role of hypoxia-inducible factors in tumorigenesis (2008, background): “It has been reported that HIF-1 can directly induce the expression of the proapoptotic genes BNIP3 and NIX in a variety of human cancer cell lines, macrophages, and endothelial cells.(98,99)”
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations. (2013, unknown): “Expression of the BNIP3 and PDK1 homologs BNIP3L and PDK3, respectively, is also induced by hypoxia in a HIF-dependent manner and contributes to mitochondrial auto-phagy and metabolic reprogramming in cancer cells (33–35).”
The mitophagy pathway and its implications in human diseases (2023, background): “286,287 291 – 294 Therefore, how cancer cells adapt to hypoxic conditions may depend on the cell type.”
Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation (2003, unknown): “Furthermore, the hypoxia-inducible proapoptotic gene bNIP-3 is also only active in acidic environments (9, 96).”
ROLE OF BNIP3 AND NIX IN CELL DEATH, AUTOPHAGY, AND MITOPHAGY (2009, unknown): “Regulation of NIX by hypoxia in tumor cell lines is also reported.(18,19,21) In U2OS osteosarcoma cells, NIX is regulated transcriptionally and post-transcriptionally by hypoxia and p53.”