Enhanced Expression of the Transcription Factor Nrf2 by Cancer Chemopreventive Agents: Role of Antioxidant Response Element-Like Sequences in the nrf2 Promoter

By M. Kwak, K. Itoh, Masayuki Yamamoto, T. Kensler. Molecular and Cellular Biology, 2002

600 citations recorded by the source corpus.

Subfields: Molecular Biology, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/1abefc430fb9c4db1f493cb0cc368deddbc91f59

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Citations in the corpus

Transcriptional Regulation by Nrf2 (2017, background): “Indeed, in murine keratinocytes, Nrf2 has been shown to bind these sequences and overexpression of the wild-type but not a truncated form of Nrf2 lacking the N-terminal region (amino acids 1–368, including the transactivation domains) induces the activity of the isolated promoter-proximal region of ”
When NRF2 Talks, Who's Listening? (2010, unknown): “NRF2 also autoregulates its own expression through an ARE-like element located in the proximal region of its promoter, leading to persistent nuclear accumulation of NRF2 and protracted induction of its target genes (83).”
Induction of phase I, II and III drug metabolism/transport by xenobiotics (2005, background): “In addition, the presence of an ARE-like sequence in the promoter region of Nrf2 have also been shown, which may be responsible for sustaining the duration of ARE activation by providing the binding site of Nrf2 itself, as a feedback control mechanism (Kwak et aL, 2002).”
Oxidative stress in ALS: key role in motor neuron injury and therapeutic target. (2010, background): “The promoter region of the Nrf2 gene itself contains an ARE sequence, so Nrf2 may regulate its own expression levels [73];”
The Roles of NRF2 in Modulating Cellular Iron Homeostasis (2017, background): “Both GPX4 and SLC7A11 are bona fide NRF2 target genes (50, 118, 133), as are the glutathione synthesis genes c-glutamylcysteine synthetase (GCS) (153), GCLM, and glutamate–cysteine ligase catalytic subunit (GCLC) (73), so NRF2 activation was expected to protect cells against ferroptosis.”
The cytoprotective role of the Keap1–Nrf2 pathway (2011, background): “A putative ARE was found in the promoter of Nrf2, suggesting Nrf2 may regulate its own transcription in a positive feedback loop (Kwak et al. 2002).”
Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress (2003, background): “The results reported in this report, in conjunction with a number of recent reports that the Nrf2 protein is stabilized by chemical inducers of Nrf2-dependent transcription (15, 19, 25, 29, 37) have illuminated one important mechanism for Keap1mediated repression and the ability of chemical inducers”
Redox Regulation in Photosynthetic Organisms: Signaling, Acclimation, and Practical Implications (2009, unknown): “…reductase, and glutathione transferases (GTs, formerly known as glutathione S -transferases) and enzymes of the pentose phosphate pathway, such as transketolase and transaldolase, as well as components of the ubiquitin-independent 20S proteasome that degrades damaged protein (231, 379, 400).”