HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus.

By G. Semenza. Cell, 2001

957 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Physiology

View Paper: https://www.semanticscholar.org/paper/b61bade44b153b824409589abc39921933cd8302

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. C. V. Dang
2. G. Semenza
3. Ping Gao
4. Jung-whan Kim
5. H. El-Gabalawy
6. C. Hitchon
7. F. Giordano
8. Yen‐Chun Liu

In Genetics

1. C. V. Dang
2. G. Semenza
3. F. Giordano
4. H. El-Gabalawy
5. C. Hitchon
6. Navdeep S. Chandel

In Physiology

1. F. Giordano
2. H. El-Gabalawy
3. C. Hitchon
4. C. V. Dang
5. Jung-whan Kim
6. Masayuki Yamamoto
7. Ping Gao
8. G. Semenza

Citations in the corpus

• Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1 (2007, background): “Oxygen regulation of HIF-1 levels depends on the HIF-1 oxygen-dependent domain, which contains two prolyl residues (402 and 564), which are hydroxylated by prolyl hydroxylase in the presence of oxygen (4, 33, 34, 52, 70, 73).”
• Oxygen, oxidative stress, hypoxia, and heart failure. (2005, background): “at the direction of specific cellular prolyl hydroxylases (114).”
• Keap1 regulates both cytoplasmic‐nuclear shuttling and degradation of Nrf2 in response to electrophiles (2003, background): “HIF-1α and HLF are rapidly degraded by proteasomes during normoxia through the hydroxylation of specific proline and/or aspartate residues, but stabilized under conditions of hypoxia (reviewed in Semenza 2001).”
• Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. (2003, background): “…amounts of HGF and putative HIF-1 binding sites (HBSs)—both in sense and antithus to activate the invasive growth program. sense orientation—through which HIF-1 promotes gene tran- All together, these data suggest that the HGF receptor is scription in hypoxic conditions (Semenza, 2001; Figure 3A).”
• Oxidation in rheumatoid arthritis (2004, background): “process has been well studied, and relates to the exquisite regulation of a key transcription factor, HIF-1α [68].”
• Effects of short-term copper exposure on gill structure, metallothionein and hypoxia-inducible factor-1α (HIF-1α) levels in rainbow trout (Oncorhynchus mykiss) (2004, background): “HIF-1 protein expression can be detected in most normoxic cells, but HIF-1 is degraded by means of the ubiquitin-proteasome system (Semenza, 2001).”
• Molecular Biology, Biotechnology and Genomics of Flooding-Associated Low O2 Stress Response in Plants (2006, neutral): “HIF-1 leads to activation of over 60 genes involved in cell survival and glucose metabolism under anoxia (Semenza et al., 1994; Semenza, 2001).”