The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione…
By Michael T. McMahon, K. Itoh, Masayuki Yamamoto, Simon A. Chanas, C. Henderson, L. McLellan, C. Wolf, C. Cavin, J. Hayes. Cancer Research, 2001
701 citations recorded by the source corpus.
View Paper: https://www.semanticscholar.org/paper/b800c7cfef69104d2e7789751b6bc67ad2a1faa9
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
Citations in the corpus
- Nrf2:INrf2(Keap1) Signaling in Oxidative Stress (2009, unknown): “Nrf2 is ubiquitously expressed in a wide range of tissue and cell types [22] [23] [24] and belongs to a subset of basic leucine zipper genes (bZIP) sharing a conserved structural domain that is designated as a cap'n'collar domain and is highly conserved in Drosophila transcription factor CNC (Fig.”
- Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders (2010, unknown): “Curiously, the roles of the other members of the Nrf family of transcription factors (Nrf1 and Nrf3) have not been investigated in the brain even though the expression levels of brain Nrf1 are much higher than those of Nrf2 (298).”
- Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex (2004, unknown): “3 g, lanes 2 to 5), and Cul3(1-380) (from 0.”
- Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. (2008, unknown): “The phase 2 detoxification response also provides a conserved defense against oxidative stress and consists of numerous enzymes that scavenge free radicals and other reactive compounds and produce or transfer glutathione (McMahon et al., 2001).”
- Expression of Nrf2 in Neurodegenerative Diseases (2007, unknown): “The cellular mechanism for eradicating oxidative stress involves release, stabilization, and nuclear translocation of the Nrf2 transcription factor (13, 14).”