Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

By M. Ramos-Gómez, M. Kwak, P. Dolan, K. Itoh, Masayuki Yamamoto, P. Talalay, T. Kensler. Proceedings of the National Academy of Sciences of the United States of America, 2001

1,185 citations recorded by the source corpus.

Subfields: Molecular Biology, Sociology and Political Science

View Paper: https://www.semanticscholar.org/paper/4dc3e015f299b60a8d33c7273b9345d4966ddf71

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Citations in the corpus

Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response. (2009, background): “Nrf2-deficient mice are prone to chemical-induced toxicity and tumorigenesis (Aoki et al., 2001; Cho et al., 2004; Lau et al., 2008; Ramos-Gomez et al., 2001).”
The cytoprotective role of the Keap1–Nrf2 pathway (2011, background): “Indeed, studies involving chemical carcinogenesis in knockout mice show that Nrf2 protects against tumour formation in the stomach, bladder and skin (Ramos-Gomez et al. 2001; Fahey et al. 2002; Iida et al. 2004, 2007; Xu et al. 2006).”
Nrf2, the Master Regulator of Anti-Oxidative Responses (2017, background): “Treated with the carcinogen, benzo[a]pyrene, Nrf2 knockout (KO) mice exhibited a significantly higher gastric tumor burden compared to wild-type mice [99].”
An important role of Nrf2-ARE pathway in the cellular defense mechanism. (2004, background): “…oltipraz, which is currently in clinical trials, significantly reduced multiplicity of gastric neoplasm only in Nrf2+/+ mice suggesting that constitutive and inducible expression of phase II enzymes through the Nrf2-ARE pathway affect the susceptibility to carcinogenesis (Ramos-Gomez et al., 2001).”
SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. (2003, background): “For example, dietary consumption of chemoprotective antioxidants acts through Nrf2 to inhibit chemical carcinogenesis in mice, and decreases the risk of gastrointestinal and lung tumors in humans (Ramos-Gomez et al. 2001; Fahey et al. 2002; Thimmulappa et al. 2002).”
Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology. (2011, background): “Disruption of the Nrf2 gene in mice leads to enhanced sensitivity to carcinogens and the loss of chemopreventive efficacy by inducers (Fahey et al., 2002; Ramos-Gomez et al., 2001).”