D. Sinclair
Geriatrics and Gerontology · 2002–2022
A researcher in the Science corpus: 31 papers; trusts 33 researchers and is trusted by 30 researchers here, as inferred from the citation graph.
Subfields
- Geriatrics and Gerontology — 451 citations into it; #6 of 114 by trust here, #2 by citations
- Physiology — 395 citations into it; #121 of 2,276 by trust here, #52 by citations
- Molecular Biology — 377 citations into it; #6,505 of 17,773 by trust here, #2,101 by citations
- Aging — 223 citations into it; #76 of 261 by trust here, #3 by citations
- Epidemiology — 98 citations into it; #798 of 2,148 by trust here, #291 by citations
- Oncology — 87 citations into it
- Endocrine and Autonomic Systems — 45 citations into it
- Cellular and Molecular Neuroscience — 43 citations into it
Whom D. Sinclair trusts overall
Their strongest outbound trust, strongest first, inferred from their citations.
- L. Guarente
- M. Haigis
- Su-Ju Lin
- H. Tissenbaum
- B. Rogina
- Kevin J. Bitterman
- Roy A. Frye
- Rozalyn M. Anderson
- S. Imai
- C. Cantó
Who trusts D. Sinclair overall
- Luis A. Rajman
- T. Niccoli
- R. Madabhushi
- N. Khan
- M. Haigis
- C. Cantó
- R. Houtkooper
- Bor Luen Tang
- K. Chwalek
- Carlos Conde
Papers from D. Sinclair's perspective
Ordered by how strongly the researchers D. Sinclair trusts endorse each paper. Same corpus, a different order for every researcher.
- Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration (Science)
- hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. (Cell)
- AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity (Nature)
- Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. (Science)
- Negative control of p53 by Sir2alpha promotes cell survival under stress. (Cell)
- Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan (Nature)
- Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases (Proceedings of the National Academy of Sciences of the United States of America)
- Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. (Nature)
- SIRT1 transgenic mice show phenotypes resembling calorie restriction (Aging Cell)
- Sir2 mediates longevity in the fly through a pathway related to calorie restriction. (Proceedings of the National Academy of Sciences of the United States of America)
Their papers
- Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase (2004) — 3,348 citations
- Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. (2011) — 902 citations
- Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging (2013) — 1,404 citations
- DNA damage-induced alterations in chromatin contribute to genomic integrity and age-related changes in gene expression (2008) — 791 citations
- Metformin improves healthspan and lifespan in mice (2013) — 1,361 citations
- Sirtuins in mammals: insights into their biological function. (2007) — 1,731 citations
- Manipulation of a Nuclear NAD+ Salvage Pathway Delays Aging without Altering Steady-state NAD+ Levels* (2002) — 222 citations
- Yeast RecQ Helicases: Clues to DNA Repair, Genome Stability and Aging (2013) — 621 citations
- Reprogramming to recover youthful epigenetic information and restore vision (2020) — 666 citations
- Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) — 760 citations
- Why does COVID-19 disproportionately affect older people? (2020) — 969 citations
- NAD+ in Brain Aging and Neurodegenerative Disorders. (2019) — 660 citations
- Therapeutic potential of NAD-boosting molecules: the in vivo evidence (2018) — 762 citations
- Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds (2016) — 748 citations
- The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice (2014) — 870 citations
- Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators (2013) — 612 citations
- The Intersection Between Aging and Cardiovascular Disease (2012) — 1,360 citations
- SIRTUIN 1 AND SIRTUIN 3: PHYSIOLOGICAL MODULATORS OF METABOLISM (2012) — 677 citations
- SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function (2012) — 1,566 citations
- Mammalian Sirtuins: Biological Insights and Disease Relevance (2010) — 2,040 citations