Sirtuins in mammals: insights into their biological function.

By Shaday Michán, D. Sinclair. Biochemical Journal, 2007

1,731 citations recorded by the source corpus.

Subfields: Geriatrics and Gerontology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/dcc6709250258a56d3983248a5fcd1eeb7a6cd7c

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Citations in the corpus

Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. (2010, background): “…E2F1, NF-kB, PGC-1a, LXR, and MyoD 864 Molecular Cell 38, 864–878, June 25, 2010 ª2010 Elsevier Inc. (Feige and Auwerx, 2008), and consequently, is involved in functions as diverse as cell fate determination, inflammatory responses, energy metabolism, and myogenesis (Michan and Sinclair, 2007).”
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. (2008, background): “It is well established that SIRT1 is activated by low energetic levels such as those occurring during fasting or calorie restriction (Michan and Sinclair, 2007; Rodgers et al., 2005), and it has been suggested that SIRT1 activators act, at least in part, by stimulating physiological pathways activat”
The Role of Sirtuins in Antioxidant and Redox Signaling (2017, background): “In addition to playing important roles in chromatin regulation and recruitment of transcription factors such as NF-jB, SIRT6 has also been suggested to have critical functions in other cellular processes such as gene expression, glucose homeostasis, and DNA repair (40, 64, 94, 160, 161).”
Histone Deacetylase Inhibitors in Clinical Studies as Templates for New Anticancer Agents (2015, background): “HDAC11 is the only member of Class IV family localized in the nucleus.”
Caloric restriction. (2011, background): “The sirtuin proteins (SIRT1 to SIRT 7) are NAD+ dependent deactylases that appear to regulate activity of many proteins that are related to energy metabolism, cell survival and longevity (Michan and Sinclair, 2007).”
Acetylation of tau inhibits its degradation and contributes to tauopathy. (2010, positive): “The activities of HDACs in classes I and II (HADC1–11) depend on zinc as a cofactor; the activities of class III HDACs (sirtuins) depend on the relative levels of NAD and NADH (Haigis and Guarente, 2006; Michan and Sinclair, 2007).”
The sirtuin SIRT6 regulates lifespan in male mice (2012, background): “Sirtuins are highly conserved deacetylases that have been shown to regulate lifespan in yeast, nematodes and fruitflie”
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. (2008, background): “While their role on lifespan is still a matter of intense debate (Chen and Guarente, 2007; Kaeberlein and Powers, 2007; Longo and Kennedy, 2006; Michan and Sinclair, 2007), it is well established that the sirtuins- a family of evolutionarily conserved deacetylases - play important roles in numerous ”
Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis (2010, background): “SIRTs have been demonstrated to play important roles in many physiological and pathophysiological conditions, including metabolism, cell survival, cancer, aging and calorie restriction-mediated longevity of organisms ranging from yeasts to humans [21,22].”
Epigenetic Modifications: Basic Mechanisms and Role in Cardiovascular Disease (2013 Grover Conference Series) (2014, background): “lyze deacetylation, and they are themselves regulated by posttranslational modification.(16,17) Histone lysine methylation represents another important class of histone modifi-”