Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.

By Su-Ju Lin, P. Defossez, L. Guarente. Science, 2000

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Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-related Hearing Loss under Caloric Restriction (2010, background): “A previous report has shown that life span extension by CR in yeast requires Sir2, a member of the sirtuin family (Lin et al., 2000), linking sirtuins and CR-mediated retardation of aging.”
Modulation of mammalian life span by the short isoform of p53. (2004, background): “It also provides a molecular link between the daf (INS/IGF) pathway that modulates life span in C. elegans, and the activity of Sir2, a gene shown to mediate life-span extension by caloric restriction in yeast (Lin et al. 2000).”